Pregnancy Outcomes After Gonadotropin Ovulation Induction in Women with Hypogonadotropic Hypogonadism Compared with Those in Women with Unexplained Infertility
TL;DR
Pregnancy outcomes following gonadotropin-induced ovulation in women with Hypogonadotropic hypogonadism are evaluated and compared with those observed in women with unexplained infertility (UI), while also examining clinical variables associated with treatment success.
Abstract
Objective: Hypogonadotropic hypogonadism (HH) represents an uncommon cause of anovulatory infertility, characterized by inadequate gonadotropin secretion or an impaired pituitary response to gonadotropin-releasing hormone (GnRH). The present study evaluated pregnancy outcomes following gonadotropin-induced ovulation in women with HH and compared these outcomes with those observed in women with unexplained infertility (UI), while also examining clinical variables associated with treatment success.Materials and Methods: This retrospective comparative study evaluated ovulation induction cycles in women with HH and in a comparison group of women with UI who were treated at a tertiary infertility center between 2010 and 2020. All patients underwent gonadotropin-based ovulation induction followed by intrauterine insemination. Treatment characteristics and reproductive outcomes were compared between groups, and clinical variables associated with achieving pregnancy and cycle cancellation were analyzed.Results: The two groups were comparable with respect to age, body mass index, total progressive motile sperm count, and infertility type (p>0.05). Women with HH required higher initial and total gonadotropin doses and had longer stimulation periods (p