pH-responsive biomimetic liposomes enhance targeted immunotherapy of bladder cancer.

Reinforcement of Solid Lipid Nanoparticles for Targeted PD-L1 Downregulation in Breast Cancer.

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype characterized by the absence of targetable receptors and limited therapeutic options. Its inherently low immunogenicity necessitates strategies to enhance its susceptibility to immune attack. This study aimed to enhance the antitumor immune res...

Cancer-cell-mimicking MnO2 nanoplatform delivers immunological adjuvants to enhance radio-immunotherapy

A tumor cell membrane-mimetic manganese-based nanoplatform for delivering immune adjuvants (MnO2-R848@CM) to synergistically enhance the efficacy of clinical radiotherapy and highlight the potential of the MnO2–R848@CM nanoplatform in advancing synergistic cancer radioimmunotherapy.

A Trojan horse nanoplatform overcoming delivery barriers for targeted gene immunotherapy of colorectal cancer

Programmed cell death ligand 1 (PD-L1) antibody has been shown to hold tremendous promise in curing metastatic colorectal cancer (CRC). However, the delivery efficacy of the targeted biologics limits this immunotherapy in a subset of CRC. Here we report a novel biomimetic ‘Trojan horse’ nano-delivery system for targete...

Biomimetic PLGA nanoparticles-mediated low-intensity pulsed ultrasound-triggered targeted release of C646 for esophageal cancer therapy.

Esophageal squamous cell carcinoma (ESCC) is associated with high morbidity and poor clinical prognosis among the Chinese population. Conventional chemoradiotherapy is hampered by severe systemic toxic effects and inadequate tumor-targeting performance. EP300 represents a promising epigenetic therapeutic target for ESC...

ββ -lapachone nanostructured lipid carriers: repolarization of tumor-associated macrophages for osteosarcoma therapy

Liposomes in Breast Cancer Therapy: Applications and Recent Research Progress

Breast cancer presents marked molecular and phenotypic heterogeneity, often requires prolonged treatment, and remains prone to drug resistance and recurrence. Conventional chemotherapy is still constrained by systemic toxicity and injury to non-target tissues. With a phospholipid bilayer surrounding an aqueous core, li...