Efficacy of Inhaled Colistin versus Oral Azithromycin in Preventing Exacerbation among Patients with Non-Cystic Fibrosis Bronchiectasis: A Retrospective Study
Oct 2026· International Journal of Drug Delivery Technology· Vol 16· 0 citations· 4 references
TL;DR
Recurrent exacerbation of non-cystic fibrosis bronchiectasis should be treated with long-term antibiotics, especially those with chronic Gram-negative bacterial colonization.
Abstract
Background: Non-cystic fibrosis bronchiectasis (NCFB) is a chronic lung condition that causes ongoing inflammation of the airways of the lungs, multiple lung infections and progressive airway structural damage, resulting in repeated exacerbations and poor quality of life. Recurrent exacerbation should be treated with long-term antibiotics, especially those with chronic Gram-negative bacterial colonization. Oral azithromycin is the most commonly used treatment; it is an antimicrobial and immunomodulatory agent, while inhaled colistin
Bronchiectasis is a widely recognised chronic respiratory illness classified in severity by frequency of exacerbations within the past year, percent predicted forced expiratory volume in 1 second (%FEV1), previous hospital admissions and radiological severity, among other factors. The physiological process is understoo...
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