Sep 2026· Organic and biomolecular chemistry· Vol 24, pp. 7642-7646· 0 citations
Medicine
Abstract
A visible-light-driven nickel-catalyzed cross-electrophile coupling of aryl halides with alkyl iodides has been developed using 9-fluorenone (FLN) as an inexpensive organic photosensitizer. The readily available FLN/diisopropylethylamine system enables C(sp2)-C(sp3) bond formation in moderate to high yields under mild conditions. The reaction accommodates aryl iodides, bromides, and chlorides as well as a range of primary and secondary alkyl iodides, while avoiding precious-metal photocatalysts and stoichiometric metal reductants. This study establishes FLN as a practical photosensitizer for nickel-catalyzed reductive cross-coupling.
Given the thermodynamic stability of the C(sp2)–O bond, the development of simple and efficient strategies for its functionalization holds significant practical value. In this study, we report an electroreductive, one-pot nickel-catalyzed cross-electrophile coupling (XEC) of aryl/alkenyl triflates with diverse (1°, 2...
Yi-Kun Ji, Xue-Ting Zhang, Zhou-Hang Wang et al.· ACS Catalysis· 0 citations
Sulfoximines are versatile motifs in synthetic and medicinal chemistry. Herein, we report a visible-light-induced nickel-catalyzed N-arylation of NH-sulfoximines with aryl chlorides and (hetero)aryl bromides under mild conditions without an exogenous photocatalyst. The reaction exhibits broad functional-group toleran...
The use of ester-derived electrophiles in transition-metal-free electroreductive C(sp3)─C(sp3) bond formation remains largely unexplored. Herein, we report a sacrificial-anode-enabled electroreductive cross-coupling of simple unsaturated carboxylates with unactivated alkyl halides. Aryl, alkenyl, and alkynyl carboxylat...
The coupling reaction of highly reactive heteroaryl iodides and alkyl iodides remains a longstanding challenge because of competing side reactions, including dehalogenation, hydrogenation, homocoupling, and radical dimerization. Here, we report an iron-catalyzed reductive cross-coupling of heteroaryl iodides with alkyl...
Jin-Ping Yuan, Shuang Tang, Yu Pu et al.· Organic Letters· 0 citations
In the present work, we have developed a dual triplet ketone/nickel-catalyzed strategy for C(sp3)-C(sp2) and C(sp3)-C(sp3) cross-coupling between aryl/alkyl bromides and alkyl boronic acids/boronates via an aminyl radical transfer (ART) strategy. The protocol features several attractive advantages, including mild react...
Amit Behera, Akash Bisoyi, Gayathri K. G. et al.· Organic Letters· 0 citations
A transition-metal-free, visible-light-mediated S-arylation of N-sulfinylamines using diaryliodonium salts and eosin Y efficiently affords diverse S-arylsulfinamides. This protocol tolerates both symmetrical diaryliodonium salts and unsymmetrical reagents bearing a 3,5-dimethylisoxazole (DMIX) auxiliary, enabling a h...
P. Zaikina, D. Bugaenko, A. Karchava· Organic Letters· 0 citations
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