TL;DR
This comprehensive assessment underscores the potential of flavonoids as versatile antibiofilm scaffolds while identifying critical gaps that must be addressed for clinical advancement.
Overall, plant-derived therapeutics represent a promising and sustainable avenue for the discovery and development of complementary antimicrobial strategies to address the growing global burden of AMR.
Results position Salvianolic acid A and the other phytochemicals evaluated here as promising adjuvant candidates for tackling multidrug-resistant Pseudomonas aeruginosa, and warrant their continued investigation as adjunctive therapeutic options alongside conventional antibiotics.
INTRODUCTION The urgent need for novel antimicrobials to combat antibiotic resistance highlights benzimidazole derivatives as highly promising candidates. Over the past decade, extensive research has focused on the therapeutic potential of benzimidazole-based scaffolds in various pathological conditions, including bact...
Antimicrobial resistance (AMR) is a major threat to public health, causing serious issues in the successful prevention and treatment of persistent diseases. Transition metal complexes are being intensively researched as promising alternatives to traditional antibiotics for the development of novel antimicrobial therapi...
Antimicrobial resistance (AMR) has intensified the need for antibacterial agents with alternative chemical scaffolds and mechanisms of action. Plant-derived antibacterial compounds represent a chemically diverse source of bioactive molecules, but their therapeutic potential depends not only on in vitro potency but also...
Peptoids are a new class of peptidomimetics that mimic the structure of AMPs, overcoming several of these drawbacks through resistance to proteolysis and efficient, low-cost synthesis of short sequences.
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