BRCA-BC did not demonstrate increased cardiovascular risk after BC diagnosis, and the apparent inverse association with CVD likely reflects the high incidence of competing risks, which limit the window for CVD to manifest.
BCa and inherited genetic susceptibility jointly contribute to increased risk of multiple common diseases, supporting the integration of genetic risk stratification into survivorship care.
Annabelle Ashworth, Zhu-Qing Shi, Huy Tran et al.· JNCI Cancer Spectrum· 0 citations
Background: Germline pathogenic variants in BRCA1 and BRCA2 are established contributors to hereditary breast cancer, yet their separate prognostic effects in non-metastatic disease remain uncertain because they are frequently analyzed as a single group. Methods: We retrospectively evaluated 360 patients with stage I–I...
İ. Bayrakçı, R. Coşar, N. Sut et al.· Cancers· 0 citations
Germline pathogenic variants in BRCA1/2 substantially increase lifetime risks of both breast and ovarian cancers. However, whether specific mutation characteristics predispose carriers to breast-ovarian double primary cancers (DPC) and whether DPC affects ovarian cancer outcomes-particularly in the PARP inhibitor (PARP...
Tong-Xia Wang, Dan Zhao, Yue-Lin Song et al.· International Journal of Can...· 0 citations
Background & Objective: Breast cancer in women aged ≤40 years is biologically aggressive and carries a disproportionate cancer-specific mortality risk. Existing prognostic tools predominantly predict overall survival, rarely account for competing risks of non-cancer death, and have not evaluated whether primary treatme...
Umema Tariq, Yousaf Ali, Mohammad Idrees et al.· Journal of Saidu Medical Col...· 0 citations
Relevance: Breast cancer is the most common malignancy in women and one of the leading causes of cancer-related mortality.
Despite the availability of clinical and biological prognostic factors, developing simple, clinically applicable risk stratification tools
remains an important challenge.
The study aimed to iden...
I. Novikov, S. Yessentayeva, V. Makarov et al.· Eurasian Journal of Oncology...· 0 citations
Externally-validated primary breast cancer genetic susceptibility predictors are relevant for SBC risk prediction and should be prioritized for risk stratification in survivors.
A. Srinivasan, Jian Wang, Gavriel Y. Matt et al.· Journal of the National Canc...· 0 citations
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