Sep 2026· Journal of Acquired Immune Deficiency Syndromes· 0 citations
Medicine
TL;DR
Over 2005-2022, TPT prescribing shifted markedly toward initiation near the time of ART initiation, with early prescribing exceeding 70% by 2022, underscoring the need for targeted catch-up strategies.
Background: Tuberculosis (TB) remains a significant global health concern, with efforts aimed at ending the epidemic by 2035. Tuberculosis Preventive Therapy (TPT) is a key intervention to prevent progression from latent TB infection to active disease, especially in children under fifteen, who were at higher risk parti...
Jackson K. Limo, David Masinde, S. Korir· International journal of res...· 0 citations
Significant risk factors for TB incidence among HIV‐positive individuals were identified, highlighting the need for targeted preventive strategies to address these risks, particularly in high‐risk populations.
E. Etu, Edao Wajiso Kallo, Kelil Husen Lenbo et al.· Journal of Tropical Medicine· 0 citations
Abstract Background Tuberculosis-preventive treatment (TPT) is recommended for those at risk of tuberculosis, but despite encouraging trial data, evidence of its effectiveness from routine settings with diverse TPT regimens is limited. We describe routine TPT implementation outcomes in people living with human immunode...
L. Chimoyi, S. Ginindza, B. Nonyane et al.· Open Forum Infectious Diseas...· 0 citations
Background There is a significant intersection between Tuberculosis (TB) and HIV, which has contributed greatly to the disease burden, especially in Nigeria. Among approximately 1.9 million people living with HIV (PLHIV), an estimated 46,000 also had TB in 2019 alone. HIV-associated TB incidence has continuously increa...
A. Aigbokhaode, A. Jegede, N. Orhue et al.· Journal of the International...· 0 citations
Abstract Background Tuberculosis preventive treatment (TPT) is recommended for household contacts of tuberculosis (TB) patients, yet implementation gaps persist, particularly in high-burden settings. We evaluated the TB preventive care cascade and determinants of TPT initiation among household contacts of patients with...
Leticia Wüthrich, G. Muula, D. Evans et al.· BMJ Global Health· 0 citations
While tuberculosis preventive therapy (TPT) coverage among people living with HIV in Zambia has improved, uptake among HIV-negative contacts aged ≥5 years remains low. Despite evidence showing that TPT can reduce TB incidence by up to 60% in HIV-negative individuals, there is a paucity of evidence on programmatic rollo...
P. Mwaba, I. Mwaba, M. Maimbolwa et al.· PLOS Global Public Health· 0 citations
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