Quantified Brain Atrophy and Risk of Severe Mass Effect in Acute Ischemic Stroke.

White matter hyperintensity burden is associated with neuroaxonal injury in acute ischemic stroke.

BACKGROUND AND PURPOSE White matter hyperintensities (WMH) reflect accumulated microvascular brain injury in small vessel disease, yet their impact on acute-phase circulating biomarker profile after ischemic stroke remains poorly defined. We examined whether WMH burden is associated with greater circulating biomarker l...

Risk factors and clinical outcomes of cerebral edema in acute ischemic stroke: a prospective observational single-centre study

MRI improves global outcome prediction after moderate or severe traumatic brain injury

Thrombectomy improves functional outcome in large core stroke partly by preventing severe cerebral edema: a real-world mediation analysis

Objective Endovascular thrombectomy (EVT) is effective in large infarct core (LIC) stroke, but mortality and severe disability remain high when cerebral edema (CED) develops. We assessed the effect of EVT on CED and outcomes in LIC patients within 24 h of stroke onset. Methods In a prospective observational cohort stud...

Infarct volume versus NIHSS score for ischemic and bleeding risk stratification after acute ischemic stroke

Background Whether infarct volume refines assessment of recurrent ischemic stroke (IS) and intracerebral hemorrhage (ICH) risk following acute IS beyond the National Institutes of Health Stroke Scale (NIHSS) remains uncertain. We compared their performance in ischemic-hemorrhagic risk stratification. Methods We include...

Pre-treatment hemorrhagic infarct on MRI is associated with poor outcome after mechanical thrombectomy for stroke: a multicenter Bayesian analysis

Background: Hemorrhagic infarction (HI), defined as petechial bleeding within infarcted tissue, is often considered benign. However, its prognostic significance before mechanical thrombectomy (MT) remains unclear. Objective: To evaluate whether HI detected on pre-treatment MRI is associated with 90-day functional depen...