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Comparison of hiPSC-derived hepatic organoids and liver-on-a-chip systems reveal microenvironment-driven maturation

Isabel Tamargo-Rubio T. Krempel Victoria Palasantzas Bella Green G. Weijer R. Moerkens C. V. D. Van Der Woude S. V. van IJzendoorn D. Touw J. Hoogerland S. Withoff Jing-Yuan Fu
Jul 2026 · bioRxiv · 0 citations · 58 references
Biology

TL;DR

A cryopreservable and scalable workflow is developed to generate hiPSC-derived hepatic organoids that can be directly matured to either static HLOs or LoC systems, enabling matched comparison of both platforms and establishing a robust hiPSC-derived LoC platform.

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