A case of LLT occurring in the tongue of a 41-year-old female who presented with a mass on the right lateral border of the tongue for 6 months is presented.
Abstract
Lipoblastoma-like tumor (LLT) is a distinctive adipocytic neoplasm most commonly arising in the vulva of women. Lingual involvement is extremely rare. Herein, we present a case of LLT occurring in the tongue and review the relevant literature. The patient was a 41-year-old female who presented with a mass on the right lateral border of the tongue for 6 months. Microscopic examination revealed the typical features of LLT. Immunohistochemically, the tumor was positive for CD34 and vimentin, with partial positivity for CDK4 and S-100, and negative for Rb, p16, and MDM2. Fluorescence in situ hybridization (FISH) demonstrated no DDIT3 rearrangement or MDM2 amplification. Next-generation sequencing (NGS) detected no significant genetic alterations. The tumor was completely resected, and no recurrence was observed at 19 months of follow-up. Given the rarity of lingual LLT—of which only three cases, including ours, have been reported—this report expands the current knowledge base and emphasizes the need for accurate diagnosis and long-term patient surveillance.
The present case is of a male patient in his mid 50s with a 1-year history of a non-healing ulcer over the right lateral border of the tongue with impaired tongue movement who was diagnosed with LMS of the tongue on histopathological examination.
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SMARCB1/INI1
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The clinical, immunohistochemical, and molecul...
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