An irinotecan nanoprodrug self-assembled from small molecules for nitroreductase-responsive drug release
Xin-Xi Huang
Long Lin
Chang-Yu Huang
Yong-Mei Jia
Guo-Hua Zhou
Yu-Ting Chen
Pei-Lian Liu
Chen-Yue Zhan
Abstract
Active ester-mediated strategy yields nitroreductase-responsive irinotecan nanoprodrugs via small-molecule self-assembly, enabling carrier-free targeted delivery and on-demand release in hypoxic tumors with high selectivity.