In conjunction with exercise intervention studies, this paper explores how lactylation, as a key regulatory molecule, can achieve bidirectional improvement in CNS inflammation and peripheral muscle function, providing a new theoretical basis for systemic intervention strategies for PD.
An integrative model in which neuroinflammation and metabolic dysfunction function not merely in parallel, but as mutually reinforcing components of a self-amplifying pathological circuit is proposed, while acknowledging that this model remains to be fully validated and that alternative causal architectures are possibl...
Yi-Xin Fu, Jiang-Hao Yu, Lu Xu et al.· Frontiers in Immunology· 0 citations
This review focuses on the potential molecular mechanism underlying KLF4-mediated neuroinflammation, oxidative stress, mitochondrial dysfunction, and apoptosis and targeting them appears to be a viable therapeutic strategy for treating PD.
Anjali Kumari, K. Aran· Current Medical Science· 0 citations
The alterations in glucose metabolism and mitochondrial metabolism in neurons, astrocytes and microglia in AD and their relationship with neuroinflammation are summarized, while also discussing some unaddressed questions, outlining therapeutic strategies, and future promising directions.
Yinuo Lei, Liyang Liu, Yi Tang· Ageing Research Reviews· 0 citations
This review systematically elaborates the potential molecular mechanisms through which KD protects against PD, which covers the improvement of cerebral energy metabolism, antioxidant and anti-apoptotic activities, suppression of neuroinflammation, regulation of α-synuclein pathological aggregation, and modulation of gu...
Mula A, Yan Bai, Yu-Lin Wang et al.· Frontiers in Nutrition· 0 citations
Overall, this review makes a case for integrative, pathway-based therapeutic models, and multiple approaches may facilitate for drug development, biomarker identification and patient management in Alzheimer's disease.
Convergent preclinical and emerging human evidence supports the PGC-1α/FNDC5/BDNF pathway as a central mediator of exercise-induced neuroprotection, while chronic IL-6 elevation and IGF-1 decline emerge as bidirectional drivers of muscle and brain ageing.
Dhika Dharmansyah, Laili Rahayuwati, I. Defi et al.· Experimental Gerontology· 1 citation
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