This review focuses on exosome-derived proteins and small non-coding RNAs as promising non-invasive biomarkers for stroke, PD, and AD, given the accessibility and stability of exosomes in biological fluids, and examines their potential diagnostic and therapeutic relevance.
This work incorporates disease-specific mitochondrial pathology with current progress in targeted nanotherapeutics, age-associated delivery barriers, clinical revolution, and emerging artificial intelligence (AI)-enabled precision therapeutic approaches to improve therapeutic outcomes in aging-associated neurodegenerat...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin Waghamode et al.· Advanced Healthcare Material...· 1 citation
This review delineates the critical functions of specific miRNAs in orchestrating the three primary pathological pillars of AD: amyloid-β (Aβ) buildup, chronic neuroinflammation, and systemic oxidative stress.
Manivannan Subramanian, Aditi Singh, Amit Singh· Journal of Dementia and Alzh...· 0 citations
The urgent need for reliable biomarkers, early diagnosis, and multidisciplinary disease-modifying strategies for future therapeutic interventions is highlighted, with particular emphasis on challenges associated with bench-to-bedside translation.
Jeewanjot Singh, Subhi Sharma, Prabhjot Singh et al.· 0 citations
This review comprehensively summarizes recent advances in brain organoid technology and its applications in modelling AD and PD and represents a transformative platform for studying the pathogenesis of neurodegenerative diseases and accelerating translational neuroscience.
P. Balaji, Nandhini Jayaprakash· SN Comprehensive Clinical Me...· 0 citations
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