This review focuses on the roles and mechanisms of writer‑mediated m6A modification in various immune cells but also summarizes its pharmacological modulators, which represents a key advantage over previous reviews.
This review systematically dissects how dysregulated m6A methylation fuels malignant transformation and progression by reinforcing core oncogenic hallmarks, sustained proliferation, metastasis, metabolic rewiring, and resistance to programmed cell death.
Sheng-Jie Tang, Rangping Xie, Jiang Fu et al.· Molecular Cancer· 0 citations
Despite advances in prevention and treatment, aging and age-related diseases remain major causes of morbidity and mortality worldwide. N6-methyladenosine (m6A) is a prevalent internal modification of eukaryotic mRNA that regulates RNA splicing, export, stability, translation, and decay. In this comprehensive narrative...
Yu-Ting Meng, Tian-Xing Liu, Ming-Hui Ru et al.· Archives of gerontology and...· 0 citations
It is argued that while epitranscriptomics represents a compelling regulatory axis in cancer cell death, advancing the field will require integrative, high-resolution, and functionally precise approaches to move beyond correlative frameworks toward mechanistic and clinically actionable insights.
A. Mukherjee, Ankit Kumar Bharti, D. Mathew et al.· Functional & Integrative Gen...· 0 citations
The m6A regulatory system, the biological characteristics of major ncRNA classes, and the mechanisms through which m6A and ncRNAs interact in cancer are summarized.
Nan Li, Jia-Xue Lu, Wen-Ling Zhang· International Immunopharmaco...· 0 citations
This review systematically summarize the functional roles of m6A regulators, including writers, erasers, and readers, in breast cancer biology and highlights the emerging clinical potential of m6A regulators as diagnostic and prognostic biomarkers, as well as therapeutic targets for overcoming drug resistance.
Zilong Chen, Chi Zhou, Zhuo-Run Song et al.· Cancer Treatment and Researc...· 0 citations
Empirical evidence elucidating how m6A regulators remodel cystine import, GPX4-dependent antioxidant defense, FSP1 signaling, lipid metabolism, iron handling, autophagy and tumor-microenvironmental communication is synthesized.
Qing-Miao Shi, Yang-Ni Li, Chao Guan· Frontiers in Cell and Develo...· 0 citations
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