It is shown that aberrant m ⁶ A modification is widely involved in the development of various tumors by regulating the expression of oncogenes and tumor suppressor genes, thereby influencing malignant phenotypes such as tumor proliferation, metastasis, metabolic reprogramming, immune evasion, immune evasion, and drug resistance.
This review systematically dissects how dysregulated m6A methylation fuels malignant transformation and progression by reinforcing core oncogenic hallmarks, sustained proliferation, metastasis, metabolic rewiring, and resistance to programmed cell death.
Sheng-Jie Tang, Rangping Xie, Jiang Fu et al.· Molecular Cancer· 0 citations
The m6A regulatory system, the biological characteristics of major ncRNA classes, and the mechanisms through which m6A and ncRNAs interact in cancer are summarized.
Nan Li, Jia-Xue Lu, Wen-Ling Zhang· International Immunopharmaco...· 0 citations
This review focuses on the interplay between immunity and epitranscriptomics and explores the direct and indirect effects of m6A modification on T cells and highlights the pivotal role of m6A regulation in T cell biology and its potential to optimize next-generation immunotherapies.
Yumna A. Butt, Nordin D. Zandhuis, I. Foskolou· Immuno· 0 citations
The tumor suppressor protein p53 is an often-mutated transcriptional factor in metastatic malignancies. The mutations result in the protein acquiring new oncogenic capabilities and/or losing canonical suppressor functions, either way contributing to cancer growth and resistance to conventional radio- and chemo-therapy....
Jorge Luis Vargas-Navarro, Joaquín Alberto Padilla-Flores, Juan Carlos Granados-Rivas et al.· International Journal of Bio...· 0 citations
Non-coding RNAs serve as key regulators of gene expression at both the transcriptional and post-transcriptional levels. Among them, piRNAs, a class of small non-coding RNAs, have emerged as significant mediators in cancer biology. PIWI proteins, members of the Argonaute family highly expressed in germline cells, intera...
A. Nakhaei, A. Omidkhoda, Farzaneh Abbasinezhad-Moud et al.· Iranian Journal of Basic Med...· 0 citations
A framework for understanding the regulatory networks of m6A-PTMs crosstalk in disease pathogenesis, development, and therapeutic response is provided, highlighting potential treatment strategies based on this interplay and suggesting future research directions.
Xinyi Li, Li-Ting Yang, Xian-Min Zhou et al.· Biochimica et Biophysica Act...· 0 citations
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