TL;DR
Young-onset bladder cancer survivors experience a sustained elevation in second primary malignancy risk, underscoring the importance of long-term survivorship awareness and informing counseling and follow-up strategies in this population.
The exploratory risk-scoring model showed preliminary risk stratification, and SPCs detected during asymptomatic surveillance were more often diagnosed at an earlier stage than those identified after symptom onset, supporting further evaluation of risk-adapted, organ- and sex-specific surveillance strategies in methodo...
Both SPM occurrence and higher cumulative RAI doses were associated with increased mortality and support careful risk-adapted use of RAI and underscore the need for extended surveillance, particularly for those diagnosed in childhood or adolescence, as malignancies may arise many years after diagnosis.
SPCs were frequent in this hospital cohort and predominantly cutaneous, and older age was an independent predictor, while actinic keratosis was a strong unadjusted marker.
In competing-risk analyses, Black race, and basaloid histology were independently associated with increased SPC risk, while advanced stage and absence of surgery were associated with lower observed incidence, likely reflecting competing mortality.
Male gender, older age, and distant tumor stage are significant predictors of higher mortality, while chemotherapy and surgery substantially improve survival in GBC patients, highlighting the necessity for targeted interventions and personalized treatment approaches to enhance survival rates.
BACKGROUND Melanoma in young adults causes substantial years of life lost because deaths occur early. Detection pathways, reasons for consultation, and sex differences may influence tumor thickness and prognosis, but evidence in this age group remains limited. METHODS We conducted a retrospective cohort study of pati...
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