[Follow-up of the long-term survivors of transplantation and cellular therapy - SFGM-TC].

Abstract

Continuous advances in allogeneic hematopoietic stem cell transplantation (allo-HSCT) have led to a growing population of long-term survivors. The Long-Term Follow-Up (LTFU) - typically defined as starting beyond two years post-transplant - aims to prevent, detect, and manage late complications, which progressively replace disease relapses as the leading cause of morbidity and mortality. Based on a literature review and a survey conducted among centers affiliated with the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC), this workshop describes the current state of LTFU in French-speaking centers, the main categories of late toxicities, and the recommended strategies for prevention and screening. We propose a prioritization framework for the management of post-transplant complications, emphasizing the key roles of transplant physicians, organ specialists, general practitioners, nurse coordinators, and supportive care professionals. The recommendations highlight the need for a national framework to structure LTFU, ensure adequate financial recognition of its complexity, and strengthen the integration between hospital and community care to promote equity of access and high-quality survivorship care.