The purpose of this review is to explore how epigenetic alterations affect gene expression and their potential role in cognitive dysfunction associated with PD.
Abstract
Epigenetics studies inheritable characteristics and lasting cellular changes that occur without alterations in the DNA sequence. This field is crucial for understanding how environmental factors interact with genes to influence memory, learning, and cognition. In the context of neurodegenerative disorders, particularly Parkinson's disease (PD), epigenetic mechanisms may help explain the molecular basis of cognitive impairment. The purpose of this review is to explore how epigenetic alterations affect gene expression and their potential role in cognitive dysfunction associated with PD.
Overall, epigenetic modulators present a promising therapeutic approach for neurodegeneration, and continued research integrating various assays like DNA methylation analysis, histone modification analysis, non-coding RNA analysis, neuroinflammation analysis, and functional and behavioral assays in AD models is signifi...
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Increased age-related biological changes have been causally linked to various pathologies in the brain, including Alzheimer's and Parkinson's diseases. There is also evidence that schizophrenia could be included in this group of brain disorders that may actually be manifestations of a broader multisystemic premature ag...
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The current understanding of the genetic and physiological mechanisms underlying Alzheimer’s disease is reviewed and modern approaches for diagnosis and treatment are discussed.
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A recent publication by Ingram et al. revealed the importance of cellular precision in psychiatric epigenetics. Using cellular deconvolution, the authors showed that anxiety is associated with cell type-specific DNA methylation signatures reflecting stress, inflammation, and accelerated aging. These findings have criti...
K. Marečková, Yuliya S. Nikolova· Trends in Neurosciences· 0 citations
This review sought to integrate disease‐specific causative triggers with shared pathogenic pathways, focusing on neuroinflammatory signaling, oxidative imbalance, mitochondrial impairment, and disrupted protein homeostasis, in order to support multi‐target, disease‐modifying therapeutic strategies.
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Brain aging and age-associated neurological diseases, such as Alzheimer's Disease (AD), Parkinson's Disease (PD), and Amyotrophic Lateral Sclerosis (ALS), are largely attributed to epigenetic drift which is characterized by the gradual accumulation of alterations in neural cell methylation patterns over time. These met...
Alkinoos A. Armoundas, C. Piperi· Mechanisms of Ageing and Dev...· 0 citations
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