Combined Vitamin D and Resveratrol Treatment Attenuates Motor Deficits and Neurodegeneration in a 6‐OHDA Mouse Model of Parkinson's Disease in Male Mice: A Focus on Sirt1 and Lingo‐1 Pathways in the Ventral Tegmental Area
Aug 2026· Brain and Behavior· Vol 16· 0 citations· 47 references
Medicine
TL;DR
Given the neuroprotective properties of Vitamin D3 and resveratrol, this study examined whether their combined administration could modulate Sirt1 and Lingo‐1 expression and attenuate neurodegeneration in a 6‐hydroxydopamine (6‐OHDA) model of PD.
Abstract
Parkinson's disease (PD) is characterized by progressive dopaminergic neurodegeneration, leading to severe motor impairments. Lingo‐1 negatively regulates neuronal survival, while Sirtuin‐1 (Sirt1) supports mitochondrial function and oxidative stress resistance. Given the neuroprotective properties of Vitamin D3 (VitD3) and resveratrol, this study examined whether their combined administration could modulate Sirt1 and Lingo‐1 expression and attenuate neurodegeneration in a 6‐hydroxydopamine (6‐OHDA) model of PD.
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