Aug 2026· Biology· Vol 15, pp. 1351· 0 citations· 202 references
Medicine
TL;DR
The conserved mechanisms underlying the occurrence of three neurodegenerative diseases across species are reviewed, with a focus on major studies involving three invertebrate models.
Abstract
Simple Summary This article reviews the conserved mechanisms underlying the occurrence of three neurodegenerative diseases across species, with a focus on major studies involving three invertebrate models. It highlights the research history, key milestones, critical aspects, and significant achievements related to neurodegenerative diseases in these models, aiming to identify potential insights for future research on neurodegenerative diseases from various perspectives.
There are several substances that have been supposed of being a risk for the development of neurodegenerative proteinopathy and Parkinsonism, mainly the agents used in agriculture and the textile industry and the environmental risk factors.
Petr Kanovsky, K. Menšíková, Pavel Čupr et al.· Journal of neural transmissi...· 0 citations
This review sought to integrate disease‐specific causative triggers with shared pathogenic pathways, focusing on neuroinflammatory signaling, oxidative imbalance, mitochondrial impairment, and disrupted protein homeostasis, in order to support multi‐target, disease‐modifying therapeutic strategies.
Fatemeh Sadat Aldaghi, Z. Siahpoosh, Z. Salehi et al.· Brain and Behavior· 1 citation
The known immune response in PD with co-pathology incidence is integrated, highlighting synergistic interactions between α-syn, tau and Aβ and how this promotes a distinct neuroinflammatory response leading to severe neuronal loss and cognitive symptoms.
Jhodi M. Webster, Ashley S. Harms· npj Parkinson's Disease· 0 citations
Increased age-related biological changes have been causally linked to various pathologies in the brain, including Alzheimer's and Parkinson's diseases. There is also evidence that schizophrenia could be included in this group of brain disorders that may actually be manifestations of a broader multisystemic premature ag...
Júlia Rius-Bonet, Julia Gras-Font, S. Macip· The British journal of psych...· 0 citations
Several vignettes are presented that illustrate approaches to use genome-wide association studies results to clarify AD-related pathways and potential therapeutics.
Investigation of anti-α -synuclein immunotherapy as a potential disease-modifying strategy for PD found no evidence of delay in motor progression and exploratory studies suggested potential clinical activity.
A. Boehringer, L. Kalia, B. Bloem et al.· Journal of Parkinson's Disea...· 0 citations
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