Open access
MHC-II deficiency in a large Algerian cohort: Clinical, immunological, and genetic characterization
Lydia Lamara Mahammed
Brahim Belaid
Ko-On-Wing Chan
Ayda Mohand-Oussaid
O. Drali
A. Dehimi
D. Leung
L. Berkani
Hassiba Sakhri
Asmaa Abed
Meriem Tahir
Fatma Merah
Amina Salmi
W. Messadi
Souhila Melzi
Jing Yang
Xing-Tian Yang
J. Stoddard
Julie E. Niemela
Heather Kenney
Fella Dahmoune
Fairouz Guerrouche
Ahlem Mechali
Amina Saad-Djaballah
Lamia Amirat
Meriem Oussalah
Yacine Inouri
S. Dib
Fatima Benbida
Chahynez Boubidi
Hind Ismahen Titri
L. Sekfali
S. Azzouz
Amel Laredj
Fadela Bendaoud
Halima Zerguine
D. Hadef
A. Kadi
D. Elhadef
H. Boucenna
Khadidja Benallal
Moufida Djalab
C. El Mezouar
Rachid Bouhdjila
M. Bessahraoui
N. Bensaadi
F. Mehdid
M. Benakli
F. Harieche
R. Aboura
Z. Zeroual
L. Smati
Salih Bendeddouche
Reda Belbouab
A. Mekki
B. Bioud
S. Ladj
M. Gharnaout
A. Ladjouze
Ourida Gacem
Nafissa Benhalla
J. R. Rosa Duque
S. Rosenzweig
L. Notarangelo
Yu-Lung Lau
R. Djidjik
Medicine
Abstract
This study characterizes the clinical, immunological, and genetic spectrum of MHC-II deficiency in the largest cohort reported to date. It identifies recurrent and novel variants and reveals genotype–phenotype differences.