Oct 2026· Carbohydrate Research· Vol 570, pp.
110125
· 0 citations· 171 references
Medicine
Abstract
Carbohydrates are essential biomolecules in nature for their numerous biological functions. To advance in-depth understanding of complex biochemical processes, obtaining pure, structurally well-defined carbohydrates is crucial. Despite extensive progress, achieving high yields with precise anomeric stereocontrol through chemical glycosylation remains a long-standing challenge. In the last few years, redox-catalyzed C-S bond activation strategies have opened new opportunities in glycosylation chemistry by enabling catalytic activation of thio-glycosyl donors. In particular, photoredox, electrochemical, and radical-mediated approaches have emerged as versatile tools, offering efficient and highly stereoselective glycosylation pathways. These methods expand the scope of thio-donor activation and provide practical routes to challenging glycosidic linkages under mild conditions. This review summarizes recent progress in the stereoselective synthesis of C-, N-, and O-glycosides via anomeric C-S bond activation, showing significant potential for synthesizing biologically relevant glycoconjugates and carbohydrate-based scaffolds.
Protecting-group-free glycosylation reduces the steps needed to convert native sugars into glycosides, but selectivity and product isolation remain major limits. This review examines methods published mainly from 2024 to August 2026. It compares donor preparation, activation conditions, linkage scope and stereochemical...
Carbohydrates play vital roles in both biological systems and materials
science. In this study, an efficient synthetic route is presented for the preparation of novel carbohydrate–
diol–sulfonate conjugates derived from sugars such as glucose and fructose. Through a sequence
involving peracetylation, selective anom...
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Qin-Bo Jiao, Zhen-Bo Guo, Shuai Jiang et al.· Journal of the American Chem...· 0 citations
C-Glycosides always significantly improve the physicochemical properties and pharmacokinetic characteristics of the native O- and N-glycosides and are one of the most powerful strategies for carbohydrate-based drug discovery. However, direct access to C-glycosides with control of stereochemistry from readily available,...
Cheng-Tao Wang, Yun-Long Xia, Xing Wei et al.· Journal of the American Chem...· 1 citation
Carbohydrate chemistry remains a cornerstone of contemporary organic and medicinal chemistry owing to the structural complexity and biological significance of saccharides. However, traditional synthetic techniques are frequently limited by poor regio- and stereoselectivity, long reaction times, harsh reaction condi...
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