MiR‑204‑5p modulates glial morphology and apomorphine‑induced rotational asymmetry without dopaminergic neuroprotection in a preclinical mouse model of Parkinson’s disease
Findings indicate that miR‑204‑5p mimic administration can modulate glial morphology and apomorphine‑induced rotational asymmetry in a severely denervated nigrostriatal system without detectable dopaminergic neuroprotection as assessed by TH immunostaining.
Background Parkinson’s disease (PD) is characterized by the progressive loss of midbrain dopaminergic (DA) neurons and aberrant α-synuclein (α-syn) aggregation, yet disease-modifying therapies that simultaneously retard neurodegeneration and foster regeneration remain lacking. Methods In this study, we isolated extrace...
Zhen Qi, Xiao-Wen Li, Xiao Jin et al.· bioRxiv· 0 citations
AIMS
Norepinephrine (NE) deficiency is an early and prominent feature of Parkinson's disease (PD), but its specific contributions to pathogenesis have not been fully elucidated. This study aims to determine whether NE exerts neuroprotective effects in PD models through the modulation of autophagy and microglial activat...
Huan Yin, Dan Zhao, Yun-Fu Wang· Experimental Neurology· 0 citations
ABSTRACT Parkinson’s disease (PD) is characterized by nigrostriatal dopaminergic (DAergic) degeneration and motor dysfunction. Many PD patients also show circadian rhythm disturbances. Increasing evidence links circadian clock dysfunction to PD pathology. REV-ERBα is a circadian nuclear receptor that regulates DAergic...
Jeongah Kim, M. Choe, Sangwon Jang et al.· Animal Cells and Systems· 0 citations
Parkinson's disease (PD) is characterized by progressive nigrostriatal degeneration, dopamine depletion, and interactions among neuronal vulnerability, oxidative imbalance, and neuroinflammatory responses. AA-2βG is a chemically stable ascorbate derivative; however, its protective profile in experimental parkinsonism r...
Peripheral immune priming can induce long-lasting changes in brain innate immune responses. In neurological diseases, including Alzheimer’s disease and stroke, inflammatory priming has been associated with neuroprotection, likely through microglial reprogramming. Here, we evaluated whether repeated peripheral histami...
Ana Vale, Catarina Serra-Almeida, J. Valero et al.· Cellular and molecular neuro...· 0 citations
This model indicates the therapeutic potential of oral NaB and provides a translational framework for investigating the mechanisms of NaB therapy in PD and associated neurological disorders and alleviated motor and non-motor deficits in rats with 6-OHDA-induced PD.
Shun-Tai Yang, Yang-Ching Chen, Tzu-Jen Kao et al.· BMC Neuroscience· 0 citations
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