Association of Serum Uric Acid Levels with Severity of Knee Osteoarthritis: A Cross-sectional Study

Association Between Obesity and Severe Knee Osteoarthritis

CORRELATION BETWEEN BODY MASS INDEX AND SEVERITY OF KNEE OSTEOARTHRITIS: A CROSS-SECTIONAL STUDY

Introduction:Knee osteoarthritis is a common degenerative joint disorder strongly influenced by mechanical and metabolic factors. Body Mass Index is an important modifiable risk factor that may influence both the onset and severity of knee osteoarthritis.Aim:To evaluate the correlation between Body Mass Index and severity of knee osteoarthritis in a cross-sectional study.Materials and Methods:This study was a hospital-based cross-sectional observational study conducted in the Department of Orthopaedics of a tertiary care teaching hospital over a period of 1 year. The study population included 100 patients diagnosed with knee osteoarthritis attending the outpatient department during the study duration who met the inclusion criteria. The main objective of the study was to evaluate the correlation between Body Mass Index and severity of knee osteoarthritis.Results:In the present study, a total of 100 patients with knee osteoarthritis were analyzed to determine the association between gender and severity of disease. Among male patients (n = 55), 28 patients (50.9%) had mild osteoarthritis, 15 patients (27.3%) had moderate disease, and 12 patients (21.8%) had severe osteoarthritis. Among female patients (n = 45), 24 patients (53.3%) had mild disease, 11 patients (24.4%) had moderate disease, and 10 patients (22.2%) had severe osteoarthritis. No statistically significant association was found between gender and severity of knee osteoarthritis thep-value was 0.41. Conclusion:Increased Body Mass Index is significantly associated with greater severity of knee osteoarthritis. Weight reduction may play an important role in preventing progression and improving clinical outcomes in knee osteoarthritis patients.

Comparison of Ultrasonographic and Radiographic Findings in Knee Osteoarthritis: A Cross-sectional Study

USG provides improved detection of osteophytes and offers additional information on soft-tissue and early structural changes in knee OA and serves as a valuable, accessible adjunct to conventional radiography for comprehensive evaluation and early diagnosis of knee OA.

The Impact of Systemic Comorbidities on the Radiographic Severity of Knee Osteoarthritis: A Cross-Sectional Analysis

Background and Aim: Knee osteoarthritis (KOA) is a highly prevalent musculoskeletal disorder associated with systemic comorbidities. However, the relationship between the radiographic severity of KOA and comorbidities remains poorly understood. This study aimed to investigate the association between common systemic comorbidities and the radiographic severity of KOA. Materials and Methods: A total of 181 patients with KOA were included in this cross-sectional study. Demographic characteristics, body mass index (BMI), and comorbidities, including hypertension (HT), diabetes mellitus (DM), thyroid disease, and other systemic comorbidities, were recorded according to the Charlson Comorbidity Index (CCI). Radiographic severity was assessed using the Kellgren–Lawrence (KL) grading system. Associations between comorbidities and KL grade were evaluated using chi-square tests. Ordinal logistic regression analyses were adjusted for age, sex, and BMI. Results: The mean age of the participants was 68.7±9.1 years, and the mean BMI was 29.4±4.5 kg/m². HT was present in 56.4% of patients with KOA, DM in 23.2%, and thyroid disease in 21.5%. Patients with HT demonstrated greater radiographic severity, with 44.1% classified as KL grades 3–4, compared with 16.5% of patients without HT (χ²=16.18, p=0.001). In the adjusted ordinal logistic regression analysis, HT remained independently associated with higher KL grades (p=0.004). No significant associations were observed between KL grade and DM, thyroid disease, other comorbidities, or CCI. Conclusion: HT was independently associated with greater radiographic severity of KOA, whereas the other evaluated comorbidities showed no significant associations. These findings support a potential role for vascular and systemic mechanisms in KOA progression and highlight the importance of cardiovascular health in patients with KOA.

Atopy is associated with osteoarthritis severity: results from the KHOALA cohort.

OBJECTIVE Atopy has been identified as a risk factor for osteoarthritis, but without specifying its impact on disease severity. We sought to investigate the association between atopy and the symptomatic and structural severity of knee and hip osteoarthritis. METHODS We used data from KHOALA, a French multicentre cohort of patients with knee and/or hip osteoarthritis (OA) investigating "atopic" subjects, defined as those with history of asthma and/or atopic dermatitis (AD) compared to "non-atopic" subjects. We compared: WOMAC pain, stiffness and function scores; and the proportion of having end-stage knee and/or hip radiographic OA (Kellgren Lawrence grade 4). Besides, we studied the cumulative incidence of total knee replacement (TKR) over 7 years of follow-up in patients with knee osteoarthritis in atopic versus non-atopic patients. Linear regression analyses of WOMAC sub-scores were adjusted for age, sex, BMI and GHQ-28 score (psychological well-being), whereas logistic regression and Cox regression analyses of radiographic end-stage disease and TKR were adjusted for age, sex and BMI. RESULTS The cohort comprised 66 atopic subjects (46 with asthma, 16 with AD and 4 having both) and 651 non-atopic subjects with a mean age of 65.2 years, 68% of whom were women, and a mean BMI of 29.3 kg/m². Atopy was associated with an increased risk of end-stage radiographic OA (adjusted OR 2.46 (1.42 to 4.25), P = 0.001), with 42% of atopic patients having Kellgren Lawrence grade 4 compared with 24% of non-atopic patients. Furthermore, over a 7-year follow-up period, atopy was associated with a two-fold increase in the risk of TKR, with an HR of 1.99 (95% CI: 1.15 to 3.45; P =0.01). Atopy was significantly associated with an increase in WOMAC pain score (7.6/20 ± 3.8 versus 6.4/20 ± 4; P < 0.05) but this association became non-significant after adjustment. Atopy was not associated with worse functional limitations or stiffness. CONCLUSION Atopy appears to be associated with the radiographic OA severity and increased requirement of knee joint replacement. These results invite us to consider atopy as a potential new determining factor in the OA disease severity.

The Association Between Knee Osteoarthritis Risk Factors and Quality of Life Among Patients with Knee Osteoarthritis in Ubung Village

Osteoarthritis is a degenerative joint disease that affects the synovial membrane, cartilage, ligaments, and bones. Several risk factors for osteoarthritis include increasing age, family history of generalized osteoarthritis, heavy physical activity, obesity, and previous joint trauma or deformity. This study aimed to identify the knee osteoarthritis risk factors associated with patients’ quality of life. A cross-sectional study was conducted among 91 patients with knee osteoarthritis in Ubung Village, Denpasar City. Data were collected using the Short Form-36 (SF-36) questionnaire to assess the quality of life of the patients. Body weight was measured using a weighing scale, and height was measured using a stadiometer to determine body mass index (BMI). The results showed that several factors were significantly associated with poor quality of life among patients with knee osteoarthritis in Ubung Village, including age >60 years (odds ratio [OR]=4.331), female sex (OR=5.571), excess body weight (OR=7.353), and vigorous physical activity (OR=3.368). Overall, 73.6% of patients demonstrated a good quality of life. However, domain-specific analysis revealed moderate to low median scores in several components, including work limitations due to physical health disorders, pain, and general health. Bivariate analysis furtherdemonstrated that age >60 years, female sex, overweight or obesity status (BMI >23 kg/m²), occupations involving heavy physical activity, and a history of knee trauma were significantly associated with poor quality of life.