Jul 2026· Journal of Diabetes and Metabolic Disorders· Vol 25· 0 citations· 122 references
Medicine
TL;DR
The definite clinical significance of APC mutations in PTC emergence is not fully understood, and additional prospective and translational studies are required to elucidate their biological and clinical advantages in diagnosis, prognosis, targeted therapy, and individualized patient management.
The present review systematically reviewed recent epidemiological trends in thyroid cancer and provided an in-depth exploration of the molecular regulatory mechanisms of key signaling pathways, including MAPK, PI3K/AKT, Janus kinase/STAT, WNT/β-catenin and NF-κB, along with their roles in the pathogenesis and progressi...
Jian Wang, Zhi Liu, Qing Zhang et al.· International Journal of Onc...· 0 citations
OBJECTIVE
Papillary thyroid carcinoma (PTC) is a well-differentiated malignancy derived from thyroid follicular epithelial cells. This study explores the functional role and underlying mechanisms of LINC01521 in PTC, aiming to provide new strategies to improve prognostic assessment and survival rates for PTC.
METHODS...
Xiaotao Duan, Zai-Kai Lin· The Laryngoscope· 0 citations
Background: Papillary thyroid carcinoma (PTC) is the most common malignant tumor of the thyroid gland. Although most patients have favorable outcomes, a subset of patients develop aggressive disease characterized by lymph node metastasis and recurrence. Increasing evidence indicates that inflammatory factors participat...
The review discusses the key genetic drivers of pancreatic carcinogenesis, including KRAS, TP53, CDKN2A, SMAD4, and BRCA1/2, and emphasizes the role of these genes as therapeutic biomarkers for the development of targeted molecular therapy.
S. Kaviya, G. Sivakumar, P. Anandhasankar· International Journal of Inn...· 0 citations
ABSTRACT Colorectal cancer (CRC) remains a major global health challenge and a leading cause of cancer-related mortality worldwide. Central to its pathogenesis is the dysregulation of interconnected signal transduction networks that govern cellular proliferation, survival, differentiation, apoptosis, and immune modulat...
Allison S Doermann, Adi Caspi, Andrew E. Evans et al.· Cancer Biology & Therapy· 0 citations
this Research Topic. In lung adenocarcinoma (LUAD), miR-582-3p promotes Wnt/ b -catenin pathway activation through suppression of PTPRCAP, whereas WTAP-mediated m6A modi fi cation decreases SOX2 mRNA stability and limits SOX2-dependent Wnt/ b -catenin signaling. In triple-negative breast cancer (TNBC), SOX10 acts as an...
S. Patergnani, D. Buchsbaum, Gary A. Piazza et al.· Frontiers in Oncology· 0 citations
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