Jul 2026· World Journal of Microbiology & Biotechnology· Vol 42· 1 citation· 142 references
Medicine
TL;DR
This review delineates the biosynthetic routes, regulatory constraints, and physiological factors involved in L-methionine and L-cysteine biosynthesis, particularly from the perspective of carbon-sulfur-nitrogen metabolic synergy.
This review presents a comprehensive analysis of recent advances in microbial BCAAs production through a Mechanism-Module-Process framework, providing a holistic roadmap for constructing superior BCAAs cell factories and extending their metabolic potential toward derivative biosynthesis.
Guihong Zhao, Si-Yu Tian, Jiong-Ran Li et al.· Biotechnology Advances· 0 citations
This review systematically summarizes current bioproduction strategies for L-cysteine, covering biocatalytic pathways and metabolic engineering of microbial cell factories and three mainstream microbial chassis, including Escherichia coli, Corynebacterium glutamicum, and Pantoea ananatis.
Ming-Li Zhao, Di Wu, Yu-Ting Liao et al.· Critical Reviews in Biotechn...· 0 citations
Ectoine, a cyclic amino acid derivative synthesized via the aspartate pathway, has emerged as a promising bioactive compound in the functional food industry owing to its exceptional protective effects on cellular structures and macromolecules. Despite its natural synthesis by halophilic microorganisms such as Halomonas...
En-Tong Zhu, Zi-Xuan Tao, Yue-Tong Fu et al.· Food Research International· 0 citations
γ-Aminobutyric acid (GABA) is a non-proteinogenic amino acid that acts as a major signaling molecule across the nervous, cardiovascular, and immune systems. While GABA has historically been produced via chemical synthesis or plant extraction, microbial fermentation using lactic acid bacteria (LAB) provides a safe, sust...
Yu-Qian Zhang, Xue Zhou, Dan Zheng et al.· Foods· 0 citations
An enzyme-constrained model was used to identify 11 gene targets affecting l-arginine production and engineered the rate-limiting enzyme argininosuccinate synthetase to construct the strain Arg11, achieving the best performance reported to date.
Shengyang He, Qi Sheng, Gang Men et al.· Bioresource Technology· 0 citations
This GRAS-certified platform establishes a highly efficient and economically viable route for the sustainable production of high-value SCP from non-food substrates, and validate a circular bioeconomy model by converting electrochemically synthesized 13C-labeled acetate into SCP.
