Open access
Plasma Proteomic Signatures Predict Incident Amyotrophic Lateral Sclerosis: A Prospective Study Stratified by C9orf72 Expansion
W.-M. Su
Qing-Qing Duan
Nan Zhang
Sheng-Yi He
Ru-Yin Liu
X.-J. Wen
Xiao-Hong Gu
Yi Wang
Bei Cao
Yong-Ping Chen
Medicine
Abstract
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurological disorder for which reliable preclinical biomarkers to predict disease onset are currently lacking. Plasma proteomics offers a promising avenue for early detection. The identification of plasma proteins and pathways associated with incident ALS holds potential to improve early diagnosis, enable risk stratification and provide insights into disease mechanisms.