Integrative exome sequencing and multi-omics analysis elucidates the regulatory role of rare variants in metabolic syndrome

Cheng-Xi Wu Jin Sang Qian Xu Ya Zhan Shan-Juan Yuan Yuan-Yuan Ge Xiu-Juan Yu Xiao Zheng Xiao-Feng Wang Xian-Mei He Chao Liu Yuan Luo Lei Zhang Yu-Fang Pei

Jul 2026 · Functional & Integrative Genomics · Vol 26 · 0 citations · 64 references

Medicine

TL;DR

A large-scale exome-wide association study in 367,188 individuals from the UK Biobank elucidates the significant contribution of rare variants to MetS susceptibility, distinct from common variant signals, and highlights the central role of lipid metabolism pathways.

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