Using generalized linear models (GLMs) and machine learning, the study identified specific metabolite ratios as potential biomarkers that can distinguish different types of endometriosis and enable mass spectrometry-based diagnostics for peritoneal endometriosis.
Evidence is provided that systemic immune-metabolic dysregulation is associated with EM and support further evaluation of blood-based biomarker strategies for non-invasive detection, however, these findings are based on a single-center cohort and require validation in independent populations and targeted assays.
Wen-Wei Pan, Guizhen Lyu, Yikang Wang et al.· Frontiers in Endocrinology· 0 citations
Emerging evidence on urinary biomarkers for endometrial cancer detection is summarized, including somatic mutations, DNA methylation markers, proteins and peptides, vibrational spectroscopy signatures, microRNAs, metabolites and urine cytology.
Molly Dore, Jiexin Cao, Holly Baker-Rand et al.· British Journal of Cancer· 0 citations
It is demonstrated that urinary EGF has potential as a novel, non-invasive, accurate and objective biomarker for endometriosis diagnosis and prognosis of this disease.
Emma R. Rashes Gertel, Cassandra C. Daisy, K. Kaplan et al.· Biomarker Research· 0 citations
It is found that eutopic endometrial stromal cells of endometriosis patients have increased deformation index and cross microchannel system faster than their counterparts of control women, which can lay the foundation for identifying a mechanical biomarker of the disease.
Urine proteomics identified disease‑related signals across cancer and metabolic conditions and may enable accurate, noninvasive classification using multiprotein panels, but given the exploratory design and its limitations, the reported accuracies should be regarded as upper-bound estimates requiring prospective valida...
B. Budnik, Hossein Amirkhani, K. Weinberger et al.· PLoS ONE· 0 citations
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