Aug 2026· Cell journal· Vol 28 1, pp.
1-14
· 0 citations
Medicine
TL;DR
Congenital hypothyroidism disrupts hormonal balance, increases oxidative stress, and induces ovarian histological alterations, and Treadmill training exerts protective effects, highlighting its potential as a non-pharmacological strategy that could mitigate reproductive complications associated with hypothyroidism.
ABSTRACT Objective The present study aimed to investigate lipolytic function in cumulus cells (CCs) from women with polycystic ovary syndrome (PCOS), with a particular emphasis on the role of androgen excess. Study Design Samples of follicular fluid and CCs were collected from 30 PCOS and 30 control subjects. Human pri...
Reza Zarezadeh, A. Fattahi, Kobra Hamdi et al.· Reproductive Medicine and Bi...· 0 citations
Pilot study results suggest potential miRNAs and their target pathway links with PCOS that need validation in larger cohorts for diagnostic or therapeutic applications need validation in larger cohorts for diagnostic or therapeutic applications.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder influenced by genetic and environmental factors, yet the molecular mechanisms linking endocrine-disrupting chemicals (EDCs) to ovarian dysfunction remain unclear. Here, we establish a letrozole-induced PCOS-like rat model and integrate bulk RNA-seq, single...
Chan Zhu, Xian-Liang Qiu, Hong Yang et al.· Journal of Steroid Biochemis...· 0 citations
ABSTRACT Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine‐metabolic disorder characterized by profound disturbances in energy metabolism, yet the molecular mechanisms underlying glycolytic dysfunction remain incompletely understood. Given the essential role of glycolysis in ovarian function and endocrine h...
Reproductive endocrine disorders are tightly linked to alterations in energy balance and metabolism, with functional hypothalamic amenorrhoea (FHA) associated with reduced energy availability, and polycystic ovary syndrome (PCOS) with metabolic dysfunction and insulin resistance, further exacerbated by obesity. M...
S. Nyunt, Thomas Hopkins, A. Le Guennec et al.· European Journal of Endocrin...· 0 citations
Findings support an association between endocrine alterations and inflammatory responses in ovarian GCs during PCOS, suggesting a potential hormone–inflammation interaction axis in the pathophysiology of PCOS.
Shao-Yu Hao, Jing Pan, Qi Zhao et al.· Journal of Ovarian Research· 0 citations
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