The smaller circadian amplitude of WTA and PAA, the lesser sleep quality, and the smaller normalized amplitude of blue light exposure, independently of photoperiod, are associated with elevated leptin in Arctic residents.
D. Gubin, S. Kolomeichuk, Konstantin V Danilenko et al.· Chronobiology International· 0 citations
The findings suggest that I394T‐C carriers exhibit features of the circadian phenotype commonly observed in older cohorts, including reduced rhythm robustness and lower melatonin levels, and support a role for this variant in interindividual differences in light sensitivity and circadian function.
Jesús Vicente-Martínez, M. Bonmati-Carrion, Ana María López-Parra et al.· Journal of Pineal Research· 0 citations
The association of UCP1 with BMI in the subjects of this study does not agree with the conclusions found in the scientific literature about an increased risk of obesity among G* allele carriers in Caucasian samples, but the associations between UCP2-3 and lipid metabolism parameters in Ob Ugrians are consistent with those reported in Mongoloid populations.
A. I. Kozlov, G. G. Vershubskaya, A. A. Vasileva· Voprosy pitaniia· 0 citations
The Circadian Imbalance Index captures a polygenic composite susceptibility signal associated with cardiometabolic and mood outcomes, with suggestive evidence of directional relationships.
Magdalena Żebrowska, M. Wielscher, Jing Zhang et al.· EBioMedicine· 0 citations
The findings underscore ambient PM2.5 exposure as a relevant environmental factor linked to impaired sleep quality and highlight that circadian epigenetic signatures could serve as molecular markers of vulnerability to pollution-related sleep disturbances.
Yuting Wang, Shuzhen Liu, Jiahui Rong et al.· Journal of Hazardous Materia...· 0 citations
Background. Bipolar disorder (BD) is characterized by circadian rhythm disruptions, contributing to mood instability and recurrence. These rhythms are regulated by clock genes in the suprachiasmatic nucleus, including the CLOCK 3111T/C (rs1801260) polymorphism that has been linked to delayed sleep phase, insomnia, and altered circadian expression. Both circadian disruption and adverse childhood experiences (ACEs) correlate with white matter (WM) abnormalities. We hypothesized that rs1801260 moderates ACE effects on WM microstructure in BD. Methods. We enrolled 137 BD patients in depressive episodes. Participants underwent 3T MRI, rs1801260 genotyping and completed the Childhood Trauma Questionnaire. Moderation (PROCESS) tested genotype–ACE interactions on whole-brain fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity (MD), and radial diffusivity (RD) values; voxel-wise TBSS (FSL Randomize) localized effects, with sex-stratified and GLZ analyses for genotype–sex interactions. Results. Significant rs1801260 × ACE interactions emerged for FA and RD across physical abuse, physical neglect, and emotional neglect. Higher ACEs were associated with lower FA/higher RD only in CLOCK rs1801260*C carriers, mainly females. TBSS showed physical abuse × rs1801260 interaction in the corpus callosum, internal capsule and corona radiata. A GLZ model with separate slopes confirmed physical abuse × sex × rs1801260 interactions on FA/RD, with effects specific to female CLOCK rs1801260*C carriers but genotype-independent in males. Conclusions. rs1801260 moderates the impact of early-life stress on WM integrity in BD, particularly in emotion-regulation tracts, with CLOCK rs1801260*C carriers showing greater vulnerability. Effects are genotype-specific in females but genotype-independent in males, possibly reflecting sex-dimorphic neurodevelopment driven by estrogen–androgen modulation of clock genes, HPA axis, and myelination.
F. Nozza, B. Bravi, L. Fortaner-Uyá et al.· Genes· 0 citations