Comprehensive multi-omics analysis identifies BTG2 as a potential regulator of radiotherapy response in lung adenocarcinoma

Abstract

Highlights • Multi-omics profiling identifies radiosensitivity subtypes in lung adenocarcinoma.• Ten clustering algorithms define robust molecular subtypes with distinct outcomes.• Single-cell and spatial transcriptomics reveal radioresponse-associated niches.• Machine learning model predicts prognosis and immunotherapy response.• BTG2 enhances radiosensitivity by suppressing glycolytic reprogramming.