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Aug 2026

Modulatory role of the mPFC orexin-2 receptors in the acquisition and expression in two paradigms of the natural- and drug-induced conditioned place preference in the rats.

A differential involvement of mPFC Orx2Rs in the acquisition and expression phases of CPP is proposed, suggesting distinguishable behavioral effects between food and morphine reward models, however, further mechanistic studies are required to clarify the underlying neural substrates.

S. Jamali, Mahboobeh Mirmohammadi, Ronak Azizbeigi et al. · 0 citations
Open access Aug 2026

Intra‐Accumbal Infusions of an α2‐Adrenoceptor Agonist and an α2‐Adrenoceptor Antagonist Respectively Inhibit and Enhance Acetylcholine but Not Dopamine Efflux in the Nucleus Accumbens of Freely Moving Rats

Findings indicate that RX 821002 enhances ACh efflux in the NAc by blocking accumbal α2‐adrenoceptor‐mediated inhibition of ACh release, which is implicated in cognitive impairment and systemic administration of α2‐adrenoceptor antagonists should be investigated for their potential to improve such deficits in experimen...

K. Arai, H. Kawashima, Y. Aono et al. · 0 citations
Aug 2026

In vivo evaluation of the dual MOP/NOP agonist AT121: a potent analgesic that delays opioid tolerance and offers a superior withdrawal suppression profile to methadone.

Dual MOP/NOP partial agonism with AT121 offers a promising strategy for effective analgesia while significantly delaying the onset of tolerance, and managing acute opioid withdrawal manifestations, while producing reduced dopaminergic activation that may indicate potentially lower abuse-related effects compared with mo...

Baraa E Elawy, Loai Aljerf, Shaza A. Allaham et al. · 0 citations
Open access Aug 2026

Dose- and time-dependent effects of the dual GIP/GLP-1 receptor agonist tirzepatide on emotional overeating in a rat model of intracranial self-stimulation

Tirzepatide does not exert a significant acute effect on feeding activity in the emotional overeating model at 30 minutes after administration, but repeated administration of the drug revealed a doseand time-dependent anorexigenic effect, manifested by a decrease in food intake on days 3 and 7 of the experiment.

N. S. Dedanishvili, S. Pyurveev, T. V. Brus et al. · 0 citations
Open access Aug 2026

Activation of dopamine D4 receptors in the nucleus accumbens shell increases motivation for palatable food and homeostatic feeding, whereas systemic blockade reduces feeding behavior in rats

Dopamine D4 receptors in the nucleus accumbens shell promote both motivational and consummatory aspects of feeding, and systemic D4 receptor blockade suppresses homeostatic feeding and motivation for palatable food, supporting an important role for D4 receptors in the regulation of feeding behavior.

J. G. Tejas-Juárez, Josué O. Suárez-Ortiz, R. E. Escartín-Pérez et al. · 0 citations
Open access Aug 2026

Effects of a selective 5-HT4 agonist and an alpha-2 adrenoceptor antagonist on etorphine-induced impairment across the oxygen cascade in immobilised sheep (Ovis aries): a randomised, prospective, and controlled trial

Etorphine profoundly impaired multiple sequential steps of the oxygen cascade in sheep, resulting in hypoxaemia, reduced DO 2 , and compensatory increases in ER, and future research is needed to develop targeted strategies that address the key mechanisms underlying the disruptions in the oxygen cascade during etorphi...

H. Rattanathanya, A. Binetti, F. Pohlin et al. · 0 citations

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