Abstract B069: Association of social determinants of health and metabolic comorbidities with cervical cancer risk and disparities
Abstract
Social determinants of health may contribute to racial disparities in cervical cancer and coexisting metabolic or chronic medical conditions. This analysis evaluated race-specific risk of cervical cancer, cervical cancer-associated metabolic disorders with acute/chronic medical conditions, and selected SDOH and healthcare-access disparities among African American (AA) and European American (EA) participants. Aggregate counts were analyzed across 493,145 overall participants in the All of Us database; our analysis included 790 participants with cervical cancer and 642 participants with cervical cancer and associated metabolic disorders and other acute/chronic health conditions. Race-specific risk ratios (RRs), odds ratios (ORs), 95% confidence intervals (CIs), and Fisher’s exact p-values were calculated. Interpersonal - SDOH domains included medication affordability, discrimination, healthcare respect/courtesy, provider communication, stress, transit access, housing stability, and delayed-care barriers. AA participants had significantly higher risk of cervical cancer compared with EA participants, with rates of 195.4 vs 153.5 per 100,000 participants, respectively (RR = 1.27, 95% CI 1.08-1.50; p = 0.0044) and higher risk in AA for cervical cancer-associated metabolic disorders with acute/chronic medical conditions compared with EA participants, with proportions of 169.4 vs 121.9 per 100,000 participants (RR = 1.39, 95% CI 1.16-1.66; p = 0.00038). Significant SDOH disparities included annual income below $25,000 (70.8% AA vs 27.6% EA), high neighborhood crime (31.4% vs 6.7%), unsafe neighborhood perception (31.4% vs 7.4%), food insecurity concern (33.3% vs 12.9%), delayed care due to transportation (23.4% vs 9.8%), and high school education or less (28.8% vs 20.0%). AA participants were more likely than EA participants to report discrimination attributed to race (29.3% vs 2.3%; RR = 12.75; p = 2.11e-08), provider race/religion being somewhat or very important (76.6% vs 57.7%; RR = 1.33; p = 0.015) and being treated with less courtesy in healthcare settings (25.0% vs 10.0%; RR = 2.49; p = 0.023). AA participants had a higher burden of cervical cancer and associated metabolic disorders, and reported more racial discrimination, poorer healthcare experiences, and higher preference for provider race or religion. Jenae Sanders, Tanvi Bhatia, Murugesh Eswaran, Briana Brock, Rajesh Singh, James W. Lillard, Brian Rivers, Desiree Rivers, Shailesh Singh. Association of social determinants of health and metabolic comorbidities with cervical cancer risk and disparities [abstract]. In: Proceedings of the 19th AACR Conference on the Science of Cancer Health Disparities; 2026 Oct 18-21; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2026;35(10 Suppl):Abstract nr B069.