A Bayesian Time-Varying SEIARD Model for State-Level COVID-19 Transmission and Mortality in the United States

Abstract

We conduct a retrospective analysis of COVID-19 transmission dynamics across U.S. states using a modified population-based Susceptible-Exposed-Infectious-Asymptomatic-Recovered-Deceased (SEIARD) compartmental model. The proposed framework introduces time-varying transmission, reporting, and mortality rates to capture temporal variations in public behavior and policy interventions during the pandemic. In particular, the transmission rate is modeled as a function of population mobility (derived from Google Mobility Reports), with a residual time-decay term capturing the net effect of unobserved factors such as behavioral adaptation and control measures, while reporting is linked to nationwide testing strategies. We employ a Bayesian approach to integrate multiple data sources and quantify uncertainties in model parameters. The model explicitly distinguishes between symptomatic and asymptomatic infectious individuals and links the latent epidemic states to observable quantities, including reported cases and deaths, through a dynamic reporting function. This retrospective modeling framework provides insights into state-level epidemic trajectories and supports data-driven decision-making for optimal allocation of healthcare resources and evaluation of public health interventions during future pandemics. We further apply a clustering analysis to the posterior parameter estimates to identify groups of U.S. states exhibiting similar epidemiological characteristics, revealing substantial regional heterogeneity in transmission intensity, reproduction dynamics, and mortality burden.