How shared structures and genomic locations of immune evasion molecules relate to function and host speci fi city is explored in the context of therapeutic options for these immune evasion molecules in infectious as well as in in in fl ammatory diseases.
This review synthesizes current evidence to show that phylogenetically diverse ESKAPE pathogens have convergently evolved conserved strategies to evade host immunity under comparable selective pressures, and identifies conserved host-directed therapeutic targets that may complement conventional antimicrobial therapy ac...
U. Nabieva, Dilorom Abdusamatova, Aziz Kubaev et al.· European Journal of Microbio...· 0 citations
This review highlights how immune evasion in Cryptococcus is mediated not by a single determinant, but by an integrated and dynamic network of structural, metabolic, and immunoregulatory processes that help refine mechanistic models of cryptococcal pathogenesis and inform future host-directed and antifungal therapeutic...
Y. P. Calegari-Alves, Luana Carolina Cardozo, W. Beys-da-Silva et al.· ACS Omega· 0 citations
A staged view highlights how mechanoadaptive anchoring, redundancy and multifunctionality can contribute to robust infection phenotypes and suggests therapeutic opportunities involving allosteric modulation, decoy-based restoration of host pathways and multi-target biologics.
Guang-Qiang Jia, Ke-Wei Chen, Hai-Jiao Lin et al.· FEMS Microbiology Reviews· 0 citations
Microbial pathogens have evolved sophisticated strategies to disseminate within hosts, yet the full repertoire of intercellular transmission routes remains incompletely understood. Traditional models of microbial spread emphasize free-particle diffusion and direct cell-to-cell contact. Here, we extend our recently prop...
Mingyan Feng, Lei-Liang Zhang· Journal of Infection· 0 citations
Extraintestinal pathogenic Escherichia coli (ExPEC) is among the bacterial pathogens associated with infections of the female and male reproductive tracts, where it may contribute to inflammatory processes and impaired reproductive function. In this context, neutrophils constitute a critical component of host defense t...
G. Bertolotto, P. Uribe, Bárbara Rosales et al.· International Journal of Mol...· 0 citations
An updated and comprehensive overview of the biological mechanisms that contribute to the success of C. tropicalis as an emerging opportunistic pathogen is provided and key areas requiring further investigation are identified to improve diagnosis, treatment, and the development of novel antifungal strategies.
Manuela Gómez-Gaviria, Dario A. Baruch-Martínez, H. Mora-Montes· Microorganisms· 0 citations
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