A lateral flow assay strip based on AND logic gate and DNA self-assembly for dual miRNA detection in breast cancer diagnosis

A DNA Nanoplatform with Rolling Circle-DNAzyme Feedback Programming for Autonomous Exponential Amplification Enables Multiplexed Orthogonal miRNA Profiling toward Precise Diagnosis of Bladder Cancer

Simultaneous and sensitive detection of multiple microRNAs in complex biological and clinical serum samples is critical for early and accurate bladder cancer (BC) diagnosis. Here, by integrating I-R3-mediated self-cleavage-coupled feedback amplification into three independently programmed circular templates, we devel...

A Dual-Mode Fluorescent and Colorimetric Biosensor Based on AuNPs@RCA Nanogel-Integrated Multipedal DNA Walker for Ultrasensitive miRNA Detection.

A dual-mode fluorescence-colorimetric biosensing platform for the ultrasensitive detection of miRNA-21, integrating AuNP-supported dual-stage rolling circle amplification (RCA) with an RCA-generated multipedal binding-and-cleavage mechanism, demonstrating excellent specificity and distinguished the endogenous responses...

Programmable hairpin assembly circuit-cascaded DNAzyme amplification for ultrasensitive miRNA-146a detection via high-stable perovskite nanocomposite biosensor.

Entropy-driven amplification combined with CRISPR-Cas12a to develop a dual-mode biosensor for breast cancer miR-155 detection

DNA Tetrahedral Nanoprobes-Based Logic-Gated FRET Sensor for in Situ Analysis of Dual MicroRNAs in Extracellular Vesicles

Conventional analysis of extracellular vesicle (EV)-derived microRNAs relies on vesicle lysis and RNA extraction, which disrupt native vesicular structure and eliminate intravesicular molecular cargoes. Here, we report a rigid DNA tetrahedral nanoprobes-based logic-gated Förster resonance energy transfer (FRET) plat...

A Co-locked hairpin probe enabling triple-cascaded signal amplification for the photoelectrochemical detection of dibutyl phthalate.

The sensitive detection of dibutyl phthalate (DBP) is essential for environmental pollution assessment and health risk warning. Although the DNA-based cascade signal amplification strategy can significantly improve the detection sensitivity, non-specific background leakage during amplification remains an unavoidable is...