Among them, compound 1 displayed the most potent anti-inflammatory activity, with an IC50 value of 9.05 ± 1.60 μM, comparable to that of the positive control dexamethasone.
Abstract
A phytochemical investigation of the stems of Dendrobium nobile Lindl. led to the isolation of six nitrogen-containing compounds, including one previously undescribed quinoline–aspartic acid hybrid alkaloid, dendronobiline A (1), together with five known alkaloid-related constituents (2–6). The structure of compound 1 was elucidated by comprehensive spectroscopic analyses, including HRESIMS, 1D and 2D NMR experiments, and its absolute configuration was assigned by comparison of experimental and calculated ECD spectra. Structurally, compound 1 features a quinoline-derived unit connected to a dimethyl aspartate moiety through an amide linkage. All isolated compounds were evaluated for their inhibitory effects on LPS-induced nitric oxide production in RAW264.7 macrophages. Among them, compound 1 displayed the most potent anti-inflammatory activity, with an IC50 value of 9.05 ± 1.60 μM, comparable to that of the positive control dexamethasone. These findings enrich the chemical diversity of D. nobile alkaloids and suggest that its stems are a promising source of anti-inflammatory natural products.
Phytochemical investigation of the methanol extract of L. wallichii roots led to the isolation and structural elucidation of four previously undescribed compounds and eight known analogues, positioning them as promising anti-inflammatory and anti-cancer agents.
Ninh Khac Thanh Tung, Oanh Thị Tú Nguyễn, Giáp Hữu Trần et al.· Phytochemistry· 0 citations
Coreopsis tinctoria Nutt., a traditional edible and medicinal plant, is recognized for its bioactive compounds with potential health benefits. In this study, eight previously unreported compounds including a biflavone (1), an acylated flavonol glycoside (2), an acylated aurone glycoside (3), five phenolic bisabolane-ty...
D. Abdurehman, Yindengzhi Guoruoluo, Jun Li et al.· Phytochemistry· 0 citations
Phytochemical investigation of the leaves of Lansium domesticum (Meliaceae) resulted in the isolation of 10 glycosides, including three previously undescribed glycosides, designated as landomsides A-C (1-3). The structures of these glycosides were elucidated using extensive spectroscopic analyses (HRESIMS, 1D/2D NMR, a...
H. Q. Nguyen, Hien Thi Tran, L. T. Thao et al.· Carbohydrate Research· 0 citations
Angeloylgomisin O (31) exhibited anti-neuroinflammatory activity by inhibiting lipopolysaccharide (LPS)-induced overproduction of nitric oxide (NO) in BV-2 microglial cells and exhibited notable neuroprotective effects against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injuries in SH-SY5Y cells.
Fengbei Gong, Pei-Kun Tian, Ning-Yuan Gong et al.· Phytochemistry· 0 citations
Tetradium ruticarpum is a commonly used medicinal herb in China that has been widely applied to alleviate clinical symptoms such as abdominal distension, abdominal pain, vomiting, and diarrhea. In the present study, total alkaloids were prepared from Tetradium ruticarpum by hydrochloric acid extraction. From these tota...
Seven previously undescribed compounds (1-7), including two norsesquiterpenes (1 and 3), one cadinane-type sesquiterpene (2), one flavonoid (4), and three xanthones (5-7), along with 17 known analogs (8-24), were isolated from the ethyl acetate extract from the fruits of Hypericum ascyron L. Four pairs of enantiomers (...
Zhang-Rui Liu, Wen-Fei Cai, Bo Wei et al.· Fitoterapia· 0 citations
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