Initial evidence for a novel role of FOXP3 as a tumor suppressor in T-ALL through modulation of TAL1 transcriptional activity is provided through modulation of TAL1 transcriptional activity.
It is found that CD9 overexpression is associated with leukemic T cells that have migrated outside the thymus into peripheral tissues and CD9 expression is heterogeneous, tends to increase at relapse and is enriched in the TAL1 molecular subtype.
J. Quessada, Mathis Nozais, Charlotte Savey et al.· Cancer Gene Therapy· 0 citations
Findings identify NTMT1 as a candidate regulatory node associated with MYC activation and downstream HLA-A suppression, warranting further mechanistic and in-vivo investigation, and highlighting NTMT1 as a promising candidate for future therapeutic investigation.
Jin-Ling Zhang, Chen Chen, Huibin Song et al.· Frontiers in Immunology· 0 citations
It is demonstrated that SETD5 contributes to T-ALL progression by regulating transcriptional programs that contribute to leukemic cell migration and infiltration, suggesting that SETD5-associated transcriptional programs warrant further investigation as potential vulnerabilities in T-ALL.
Ming-Yue Hao, Yu-Jie Bian, Mengke Li et al.· Experimental Cell Research· 0 citations
A molecular mechanism by which KLF4 governs AML progression is revealed, providing a novel therapeutic target and a potential small-molecule inhibitor for AML treatment.
Meng Yang, Ting Lu, Yi-Cheng He et al.· Leukemia· 0 citations
This review focuses on the interplay between immunity and epitranscriptomics and explores the direct and indirect effects of m6A modification on T cells and highlights the pivotal role of m6A regulation in T cell biology and its potential to optimize next-generation immunotherapies.
Yumna A. Butt, Nordin D. Zandhuis, I. Foskolou· Immuno· 0 citations
Histone lactylation is an epigenetic modification that connects lactate metabolism with protein function. Our study identified lactate enhances the protein lactylation level not only in Myeloid-derived suppressor cells (MDSCs) of tumor-bearing mice, but also in the tumor tissues of lung cancer patients. This modificati...
Yao Dai, Hai-Yan Dai, Ya-Hui Wang et al.· Cancer immunology research· 0 citations
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