A dual-mode photothermal/colorimetric aptasensor using CD63 aptamer-functionalized core-shell AuPt nanozymes for detecting GC-related CD63-positive exosomes in serum samples and providing a dual-mode tool for quantitative GC-related exosome analysis and preliminary extracellular vesicle monitoring is developed.
Conventional methods for detecting Salmonella Typhimurium in food often require lengthy procedures or specialized instrumentation. We developed a dual-mode aptasensor based on magnetic covalent organic frameworks (MCOFs) and MnO2 nanozymes. MCOF-AuNPs@apt captures bacteria, followed by MnO2@apt binding to form sandwich...
Hang Li, Xin-Rui Wang, Fu-Ru Lei et al.· Food Chemistry· 0 citations
This study presents the synthesis and evaluation of a novel multifunctional bimetallic nanocomposite comprising gold (Au) and cadmium (Cd) nanoclusters (NCs) embedded within bovine serum albumin (BSA) nanoparticles for advanced cancer theranostics. The structural and optical properties of the Au-Cd/BSA nanocomposites w...
Shayan Shahsavari, Mohammad Behnam Rad, Fatemeh Sadat Mahdavi et al.· Scientific Reports· 0 citations
The sensitive, point-of-care detection of acute myeloid leukemia (AML)-derived exosomes is essential for non-invasive diagnosis and therapy monitoring, but remains technically challenging. Here we report a colorimetric biosensor based on a dual -aptamer-initiated catalytic cascade, where simultaneous recognition of exo...
Ying Shen, Yunlong Xiao, Lu Liu et al.· Analytica Chimica Acta· 0 citations
Breast cancer-associated miRNAs are promising liquid-biopsy biomarkers, but their low serum abundance, short sequences and matrix interference hinder sensitive and multiplexed detection. Herein, we developed an Ag NPs@MXene-mediated electrochemical-surface-enhanced Raman scattering (EC-SERS) dual-mode microfluidic arra...
Xiao-Shuang Chen, Heng-Ji Li, Jin-Yao An et al.· Bioelectrochemistry· 0 citations
Rapid quantification of capsaicinoids (CAPs) is critical for identifying recycled cooking oil and the grading of chili pepper pungency. In this study, a CAPs-specific monoclonal antibody and trimetallic core-shell Au@PtPd nanoparticles (Au@PtPd NPs) were prepared, the bare Au@PtPd NPs exhibited excellent antibody-bindi...
Jiaxi Li, Yuyang Chen, Shu-Xian Li et al.· Talanta: The International J...· 0 citations
Circulating tumor cells (CTCs) are critical biomarkers for cancer prognosis and treatment monitoring, yet their detection remains challenging due to low abundance and phenotypic heterogeneity. Herein, we developed a dual-aptamer-conjugated electrochemical cytosensor using an in situ catalase (CAT)-encapsulated nanozyme...
Na Gan, Peiran Liu, Ting-Ting Zeng et al.· ACS Sensors· 1 citation
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