This review elaborates on the latest design optimization strategies and research advances of next-generation function-enhanced ADCs, focusing on four core directions: bispecific ADC construction, internalization efficiency improvement, binding affinity enhancement, and payload combination innovation.
This review examines the structural and biologic features that determine clinical activity, including target selection, linker stability, payload class, drug-to-antibody ratio, tumor penetration, biomarkers, toxicity, and resistance.
A. Philipovskiy, Scott Shurmur, Muhammad Bilal Abid· Cancers· 0 citations
Contin improvements in antibody engineering, linker optimization, payload development, computational modeling, and biomarker-guided patient selection are expected to further improve the therapeutic index and translational success of bsADCs in cancer treatment.
This article provides a systematic synthesis of extant research, thereby facilitating the future advancement of targeted conjugate drugs toward greater precision and individualization.
This review discusses the important components of ADC design in the context of clinical successes and failures, and evaluates mechanisms of intrinsic and acquired resistance and strategies to overcome these barriers.
N. Shah, F. Meric-Bernstam· Journal of Experimental Medi...· 0 citations
Preclinical investigation of trastuzumab-encapsulated actinomycin D, a HER2-targeted AED, has demonstrated potent antitumor activity across cancer models with varying HER2 expression levels, alongside a favorable toxicity profile in animal models, position AED as a promising next-generation targeted cancer therapy that...
Lin-Rong Li, Armando E. Giuliano, Qiang Sun et al.· Cell investigation· 0 citations
Continual advances in molecular engineering and precision biomarker strategies are redefining ADCs as versatile platforms for precision oncology and may enable broader, potentially tumor-agnostic, applications in solid tumors.
H. P. Luqmana, A. Ashariati, M. Savitri et al.· Immunological Investigations· 0 citations
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