Kinase regulation of miRNA networks in cardiometabolic disease: emerging pathways to precision therapy

Circular RNAs and SIRT1 in post-transcriptional regulation and human disease.

The circRNA-SIRT1 network is proposed as a context-dependent post-transcriptional regulatory network linking non-coding RNA (ncRNA) biology to immunometabolic and stress-response pathways and emphasized as a promising platform for precision diagnostics and disease-specific therapeutic interventions.

Post-translational modifications in sepsis-induced myocardial dysfunction - Molecular mechanisms and therapeutic targets: A review.

Sepsis-induced myocardial dysfunction (SIMD) is a frequent and life-threatening complication of sepsis driven by interconnected inflammatory, oxidative, metabolic, and mitochondrial disturbances. Post-translational modifications (PTMs) have emerged as key regulators of these processes by dynamically altering protein ac...

AMPK as a Central Node in Cancer and Cardiovascular Diseases.

AMP-activated protein kinase (AMPK) functions as a principal regulator of cellular energy homeostasis, acting as a metabolic stress sensor that coordinates essential signaling pathways, including mTOR inhibition, autophagy induction, gluconeogenesis, and lipid metabolism. Recent research underscores AMPK's pivotal role...

Circular RNAs at the crossroads of oxidative stress: novel targets for precision therapeutics

Autophagy -Regulated Myocardial Fibrosis: From Mechanistic Exploration to Therapeutic Prospects.

Autophagy serves as a crucial modulator of myocardial fibrosis through multiple interconnected molecular pathways, underscoring the need for further research to translate these mechanisms into effective clinical interventions.

Immunity-metabolism-senescence axis in liver fibrosis: mechanistic insights, therapeutic targets, and translational opportunities.

Liver fibrosis is a dynamic and potentially reversible consequence of chronic liver injury, shaped by persistent inflammation, metabolic disturbance, and impaired tissue repair. Accumulating evidence indicates that, rather than operating as independent processes, immune activation, metabolic reprogramming, and cellular...