Jul 2026· Asian Journal of Pharmaceutical and Clinical Research· 0 citations
Abstract
Objective: To compare intravenous Dexmedetomidine and Tramadol for control of shivering following spinal anaesthesia.
Methods: This prospective, randomised, double blind study was conducted in 60 adult patients aged 18 to 60 years with ASA physical status I or II undergoing elective surgery under spinal anaesthesia. Patients who developed grade 2 or higher shivering were randomly assigned to receive intravenous Dexmedetomidine 0.5 µg/kg or Tramadol 0.5 mg/kg infused over 20 minutes. Shivering severity was assessed using the Wrench scale. Statistical analysis compared continuous and categorical variables between groups, with significance set at p < 0.05.
Results: Demographic profile and baseline parameters were comparable between groups, with equal gender distribution and similar mean body weight. Time to cessation of shivering was shorter in the dexmedetomidine group (172.7 ± 20.7 seconds) compared with the tramadol group (272.4 ± 19.0 seconds). Shivering recurrence occurred in 6.7% of patients receiving dexmedetomidine and 23.3% receiving tramadol. A significant difference was observed at T3 for pulse rate (64.9 ± 8.1 vs 69.9 ± 7.5 bpm; p = 0.02) and diastolic blood pressure (74.9 ± 6.7 vs 79.9 ± 6.9 mmHg; p = 0.006).
Conclusion: Intravenous dexmedetomidine showed faster and more sustained control of post spinal anaesthesia shivering than tramadol. Slow infusion of both drugs maintained haemodynamic stability thus proving that dexmedetomidine is an effective option for shivering control during spinal anaesthesia.
Tramadol demonstrated a shorter mean time to cessation of shivering, whereas nalbuphine showed a comparatively better adverse effect profile with less nausea and vomiting, which ensured adequate hemodynamic stability and are suitable for clinical use.
R. C, Avinash Karekal, Srinivas Kurahatti· Asian Journal of Pharmaceuti...· 0 citations
Objective: to assess the effect of Dexmedetomidine given intraoperatively compared to placebo on acute postoperative pain and requirement of analgesics after surgery.
Study Design: Quasi-experimental study.
Place and Duration of Study: Combined Military Hospital, Multan Pakistan from May to Dec 2023.
Methodology: One h...
Khurram Aslam, Abdullah, M. Saeed et al.· Pakistan Armed Forces Medica...· 0 citations
Both dexmedetomidine and ketamine were associated with low shivering rates following subarachnoid block, suggesting that ketamine may be preferable when preservation of intraoperative wakefulness is desired.
Tamanna E. Jahan, Md. Mahmudul Hasan Khan, B. C. Saha· Pacific Journal of Medical R...· 0 citations
Background: Spinal anesthesia is a very commonly used procedure in modern-day anesthesia practice. Today most of the lower limb surgeries are performed under spinal anesthesia. Midazolam, dexmedetomidine, and fentanyl are common intravenous adjuvants used during anesthesia to allay anxiety and sedation. The aim of this...
M. Rahimi, Mohamad Sorani, Afzal Shamsi et al.· Archives of Anesthesia and C...· 0 citations
Objective: To evaluate the efficacy of intranasal dexmedetomidine for postoperative analgesia in geriatric patients undergoing lower limb orthopaedic surgeries, with postoperative pain scores as primary outcome and haemodynamic stability and sedation as secondary outcome during the first 24 h.
Methods: This prospective...
U. A. Reddy, Renuka Holyachi, Santoshkumar Karjagi et al.· International Journal of Cur...· 0 citations
A single low dose of dexmedetomidine at induction significantly reduces EA in pediatric dental outpatients, without compromising day-surgery discharge feasibility despite a modest prolongation of recovery time.
Xiang Zhang, Wei Cui, Dan Qiao et al.· Frontiers in Surgery· 0 citations
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