2026· Brazilian Journal of Pharmaceutical Sciences· 0 citations· 66 references
TL;DR
Findings support the integration of pharmacogenetic information into clinical decisionmaking to optimize ASM therapy and reduce the risk of drug resistance in epilepsy management.
Abstract
ABCB1 gene polymorphisms have been associated with drug-resistant epilepsy (DRE). This integrative review evaluates the impact of key ABCB1 single nucleotide polymorphisms (SNPs)- C3435T (rs1045642), G2677T/A (rs2032582), and C1236T (rs1128503)-on the pharmacokinetics and therapeutic response to antiseizure medications (ASMs), including carbamazepine (CBZ), lamotrigine (LTG), and topiramate (TPM). Evidence suggests that these polymorphisms significantly affect CBZ and LTG efficacy by altering drug pharmacokinetics and increasing systemic exposure. In contrast, no consistent association has been observed between these variants and TPM response. These findings support the integration of pharmacogenetic information into clinical decisionmaking to optimize ASM therapy and reduce the risk of drug resistance in epilepsy management.
Overall, current evidence does not support SCN1A or ABCB1 polymorphisms as standalone predictive biomarkers for paediatric DRE, and their relevance should be interpreted cautiously and, at most, considered within broader multi-marker and clinically integrated models.
Sumreena Mansoor, Najmun Nahar, N. Farman et al.· SN Comprehensive Clinical Me...· 0 citations
A case of a 49-year-old Chinese woman with essential thrombocythaemia who was treated with voriconazole for possible invasive pulmonary aspergillosis, who required unusually high doses to achieve therapeutic voriconazole concentrations without apparent adverse effects under therapeutic drug monitoring (TDM).
Qin Hui, Y. Yuen· European Journal of Hospital...· 0 citations
VPA-induced hyperammonemia appears to be influenced by both clinical factors and genetic susceptibility, whereas liver toxicity and thrombocytopenia are primarily driven by clinical and treatment-related factors.
C.-A. Liang, P.-T. Chu, H. H. Chang· International Journal of Neu...· 0 citations
The analysis of pharmacotherapy in the study sample of post-stroke patients revealed potential undesirable drug interactions between clopidogrel and acetylsalicylic acid as a risk factor for side effects.
N. Vorobyeva, S. Sharapova, A. S. Vorontsova et al.· Pharmacogenetics and Pharmac...· 0 citations
Objective The aims of this study were to identify genetic polymorphism in solute carrier organic anion transporter 1B3 (SLCO1B3 767G>C (rs60140950)), and to examine the impacts of this polymorphism on the efficacy and safety of paclitaxel in Iraqi women with breast cancer (BC). Methods This cross-sectional observationa...
Balsam S. J. Al-Hussein, Atheer M. R. Al-juhaishi, H. M. A. Abo Almaali et al.· Journal of Taibah University...· 0 citations
No significant effect of CYP2C19 genetic polymorphism on ESC efficacy was observed in this study, which underscores the need for further exploration into the clinical utility of pharmacogenetics.
Yan-Yan Wang, Wen-Zhe Sun, Chen-Sheng Pan et al.· Neuropsychiatric Disease and...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
