Under HG conditions, silencing of SNHG12 promoted cell proliferation, inhibited apoptosis, and mitigated inflammatory responses, as well as attenuated fibrosis, reflected by decreased expression of transforming growth factor-beta 1 and alpha-smooth muscle actin.
FBXL19-AS1 appears to interact with and modulate miR-650, thereby affecting ITGB3 expression and potentially participating in the pathological progression of AD.
Jie Dou, Yan-Ping Zhu, Zili Du et al.· Hereditas· 0 citations
Pancreatic β-cell dysfunction underlies type 1 diabetes mellitus (T1DM) progression. Previous study showed that lncRNA Gm10451 is upregulated by high glucose and contributes to β-cell impairment, but its mechanism remains unclear. Interactions among Gm10451, miR-24-3p, and G6PD were validated by dual-luciferase assay a...
Jiao Wang, Li-Hai Zhang, Xian-He Wang et al.· Endocrine· 0 citations
BACKGROUND
Diabetic peripheral neuropathy (DPN) is a common intractable complication of type 2 diabetes mellitus (T2DM), lacking specific diagnostic markers and therapeutic targets.
OBJECTIVES
This study explored the clinical value of NR2F1-AS1 in DPN and clarified its molecular regulatory mechanism in DPN progressio...
Ya-Zhi Zhao, Shi-Ling Rong, Xiao-Ya Ren et al.· Molecular and Cellular Probe...· 0 citations
It is suggested that lnc-DNAJC3-AS1 promotes GC progression, at least in part, through the miR-576-5p/LYPLA1 pathway, providing a potential target for GC treatment.
Zhen-Ni Sun, Ya-Sai Yao, Zhi-Jian Xu et al.· American Journal of Cancer R...· 0 citations
Background: Type 2 Diabetes Mellitus (T2DM) is becoming a worldwide health condition. High blood glucose for a prolonged period of time increases oxidative stress. Ferroptosis is a cell death mediated by iron. May be associated with iron overload, oxidative stress and tissue damage in diabetes. MicroRNA miR-182-5p has...
Rowshen Hani Al Nakeeb, Mahmoud H. Khalaf AL-Fahdawi, Noor Dheyaa Hameed· Stallion Journal for Multidi...· 0 citations
To explore the diagnostic significance of LncRNA GAS6-AS1 in chronic heart failure (CHF) and its molecular mechanism of influencing cardiomyocyte function through the regulation of miR-152-3p. This study incorporated 126 patients diagnosed with CHF and 124 healthy control subjects. The serum level of GAS6-AS1 was deter...
Mi Li, Ning Lu, Lu-Xi Yang et al.· Journal of Cardiothoracic Su...· 0 citations
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