Skip to content

LncRNASNHG12 regulates the development of diabetic nephropathy through miR-129-5p/IL6ST axis

Aug 2026 · Molecular Biology Reports · Vol 53 · 0 citations · 38 references
Medicine

TL;DR

Under HG conditions, silencing of SNHG12 promoted cell proliferation, inhibited apoptosis, and mitigated inflammatory responses, as well as attenuated fibrosis, reflected by decreased expression of transforming growth factor-beta 1 and alpha-smooth muscle actin.

View source

Similar papers

Open access Sep 2026

lncRNA Gm10451 mediates β-cell functional impairment in type 1 diabetes through the miR-24-3p/G6PD axis

Pancreatic β-cell dysfunction underlies type 1 diabetes mellitus (T1DM) progression. Previous study showed that lncRNA Gm10451 is upregulated by high glucose and contributes to β-cell impairment, but its mechanism remains unclear. Interactions among Gm10451, miR-24-3p, and G6PD were validated by dual-luciferase assay a...

Jiao Wang, Li-Hai Zhang, Xian-He Wang et al. · 0 citations
Open access Sep 2026

LncRNA NR2F1-AS1 serves as a diagnostic biomarker for diabetic peripheral neuropathy and promotes disease progression by regulating miR-150-5p.

BACKGROUND Diabetic peripheral neuropathy (DPN) is a common intractable complication of type 2 diabetes mellitus (T2DM), lacking specific diagnostic markers and therapeutic targets. OBJECTIVES This study explored the clinical value of NR2F1-AS1 in DPN and clarified its molecular regulatory mechanism in DPN progressio...

Ya-Zhi Zhao, Shi-Ling Rong, Xiao-Ya Ren et al. · 0 citations
Open access Aug 2026

The miR-182-5p/NRF2 Axis and Inflammation Across Glycemic States in Type 2 Diabetes Mellitus: An Integrated Clinical and Molecular Study

Background: Type 2 Diabetes Mellitus (T2DM) is becoming a worldwide health condition. High blood glucose for a prolonged period of time increases oxidative stress. Ferroptosis is a cell death mediated by iron. May be associated with iron overload, oxidative stress and tissue damage in diabetes. MicroRNA miR-182-5p has...

Rowshen Hani Al Nakeeb, Mahmoud H. Khalaf AL-Fahdawi, Noor Dheyaa Hameed · 0 citations
Open access Aug 2026

LncRNA GAS6-AS1 affects doxorubicin‑induced cardiomyocyte injury in H9c2 cells by regulating miR‑152‑3p: a cellular model relevant to heart failure

To explore the diagnostic significance of LncRNA GAS6-AS1 in chronic heart failure (CHF) and its molecular mechanism of influencing cardiomyocyte function through the regulation of miR-152-3p. This study incorporated 126 patients diagnosed with CHF and 124 healthy control subjects. The serum level of GAS6-AS1 was deter...

Mi Li, Ning Lu, Lu-Xi Yang et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.