METTL3-mediated N6-methyladenosine modification of circHUWE1 promotes high glucose-induced cardiomyocyte apoptosis and ferroptosis-related alterations through regulating miR-671-5p/CELF1 axis
Jul 2026· Molecular and Cellular Biochemistry· Vol 481, pp. 4029 - 4041· 0 citations· 47 references
Medicine
TL;DR
The circHUWE1/miR-671-5p/CELF1 axis regulates HG-induced cardiomyocyte apoptosis and ferroptosis-related alterations and represents a novel mechanism underlying Dex-mediated cardioprotection.
Findings reveal that the LINC01419–miR-132-3p–USP38 axis mediates ferroptosis in vascular endothelial cells under hyperglycemia, and suggest USP38 as a potential therapeutic target for T2DM.
Ke-Ke Tang, Wen-Ji Gao, Xin-Xing Wo et al.· Scientific Reports· 0 citations
Overexpression of GAS6-AS1 could mitigate the reduction in cell viability and the elevation in apoptosis induced by DOX in H9c2 cells, and inhibit the expression of pro-inflammatory factors.
Mi Li, Ning Lu, Lu-Xi Yang et al.· Journal of Cardiothoracic Su...· 0 citations
This work indicates that m6A modification plays a critical role in autophagy, likely by downregulating TRIM62 in myocardial I/R, and aggravates myocardial I/R injury by inducing autophagy.
Wei-Song Wen, Yuan-Sheng Liu, Xin Wang et al.· Pathology, Research and Prac...· 0 citations
OBJECTIVE
To explore the expression localization, functional effects, and upstream regulatory mechanism mediated by circHIPK3 (homeodomain interacting protein kinase 3)/miR-125a-5p of NDUFA5 (NADH-ubiquinone oxidoreductase 1 alpha subcomplex 5) in diabetic retinopathy (DR) by integrating public single-cell and bulk RNA...
Zhi-Hui Zhang, Yuan-Feng Liu, Mei Bai· American journal of translat...· 0 citations
The m6A methylase METTL3 drives production of ITGβ4E to exacerbate HF via SRSF3-mediated alternative splicing of ITGβ4 mRNA, suggesting that alternative splicing of ITGβ4 may be a potential therapeutic target for HF.
Li Yao, Chao Liu, Jian Dong et al.· The FASEB Journal· 0 citations
