Design, Synthesis, Characterization and Evaluation of Anticancer Activity of Substituted-4-(Substitutedphenylhydrazon o)-3,4-Dihydroquinolin-2-(1H)-One

DESIGN, SYNTHESIS, AND PRELIMINARY ANTIPROLIFERATIVE EVALUATION OF BENZIMIDAZOLE-1,3,4-OXADIAZOLE HYBRIDS SHOWING PREFERENTIAL ACTIVITY IN BREAST CANCER CELL LINES

In this study, a new series of benzylthio-substituted benzimidazole-1,3,4-oxadiazole hybrids was designed, synthesized, and evaluated for their biological activity. The title compounds, 2-((2-(benzylthio)-1H-benzimidazol-1-yl)methyl)-5-aryl-1,3,4-oxadiazoles (1-4), were prepared through a multistep synthetic route star...

Design, synthesis, molecular docking and anticancer activity of novel N-(4-(chlorodifluoromethoxy)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives

New N-(4-(chlorodifluoromethoxy)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives were designed, synthesised, and evaluated as potential anticancer agents. Among the synthesised derivatives, compound 9c showed the highest potency against BCR-ABL1-positive K562 leukemia cells, with an IC50 of 0.26 ± 0.029 µM,...

Design, robust synthesis, and anti-liver cancer activity of 2-hydrazono-5-acetyl-[1,3,4]thiadiazole and N'-ethylideneethanethiohydrazide derivatives: In vitro, gene expression, DNA damage, and DNA fragmentation.

A novel series of 2-hydrazono-5-acetyl-[1,3,4]thiadiazole and N'-ethylideneethanethiohydrazide derivatives tested as anticancer agents against a panel of cancer cell lines, and the mechanism of action of the most active compounds against liver cancer was explored through gene expression, DNA damage, and DNA fragmentati...

Enhancement of antitumor activity through structural optimization of 2-(Benzylamino)-thieno[2,3-d]pyrimidin-4(3H)-ones

Design, synthesis and dual anticancer and antibacterial evaluation of novel 1,3,4-oxadiazole-2-thiol derivatives targeting EGFR and DNA Gyrase B: integrated docking, DFT and ADMET studies.

1,3,4-oxadiazole-2-thiol derivatives are established as promising dual-action therapeutic scaffolds for anticancer and antibacterial activities through computational and experimental approaches.

Design, Synthesis, In Vitro Cytotoxicity, and Molecular Docking of Novel 2-Thioxoimidazolidin-4-one Derivatives

These findings highlight these newly synthesized 2-thiohydantoin derivatives as promising scaffolds for the development of advanced therapeutic agents against prostate cancer.