TL;DR
The genetic liability captured by ASD PRS does not appear to predispose mothers to obstetric complications, and the observed increase in obstetric diagnoses among autistic females may instead reflect other genetic influences that are not captured through PRS and/or environmental factors.
A modest association between ART and ASD is suggested that may be shaped substantially by underlying subfertility and specific procedures rather than ART exposure alone, although between-study heterogeneity was substantial.
Hypertensive disorders, depression, and anxiety were the strongest potential mediators of those analyzed, and should be further evaluated as intervention targets, and should be further evaluated as intervention targets.
It is suggested that prenatal metabolic profiles, particularly lipid- and mitochondrial energy-related pathways in late gestation, may contribute to early behavioral and autism-related traits in a sex-specific manner, underscoring the importance of exposure timing and maternal metabolism in the etiology of neurodevelop...
A familial background of autism, male gender, premature birth, and admission to a neonatal intensive care unit were notably more prevalent in children with autism, underscoring populations who may require enhanced developmental monitoring.
Findings support low birth weight as an early marker of neurodevelopmental vulnerability across NDD outcomes.
It is suggested that family structure may represent an important early-life context for neurodevelopment and may help inform developmental surveillance in societies experiencing declining fertility rates and delayed childbearing.
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