Histological assessment of integrated human cortical organoid grafts after controlled cortical impact

Long-Term Survival and Maturation of Transplanted Cerebral Organoids Derived from Human Induced Pluripotent Stem Cells

Highlights What are the main findings? hiPSC-derived cerebral organoids survived and matured into cortical neuronal subtypes, GABAergic neurons, and glial cells at 12 months post-transplantation. Grafted cells formed synapses and achieved vascularization within the host brain. What are the implications of the main find...

Using Brain Organoids to Explore Human Neurobiology

One of the major challenges in neuroscience is understanding how the human brain develops into a highly organized and functionally integrated organ, because many developmental processes cannot be investigated directly in humans and are not fully recapitulated in animal models. Brain organoids derived from human pluripo...

Modeling perinatal brain injury with human brain organoids: from pathophysiology to treatment development

This model provides opportunities to investigate the mechanisms underlying perinatal insults and serves as a promising tool for novel treatments such as stem cell-based therapy, drug discovery and screening, helping to bridge the translational gap between preclinical studies in animal models and clinical applications.

Temporal mapping of radiation-induced neural injury and mitigation in human cortical organoids

Human cortical organoids recapitulate key features of radiation-induced neural injury, recovery, and therapeutic modulation, providing a robust, scalable, and human-relevant platform for studying CNS radiation biology and preclinical screening of candidate radiation mitigators.

Human Stem Cell Transplantation, Immunosuppression, and Noninvasive In vivo Cell Tracking in the Mouse Brain

Abstract Stem cell therapies have emerged as potential therapeutics of interest for many central nervous system diseases, including stroke, epilepsy, neurodegenerative diseases, and traumatic brain injury. Preclinical models are required to evaluate the migration of transplanted stem cells to various areas of the brain...

PTPσ mediates the integration of grafted neuronal tissueoids with host neural pathways after complete spinal cord injury.