Intestinal microbiota in neurodegeneration and ageing: Mechanisms, pathways, and therapeutic interventions.

The Gut-Brain Axis: Exploring the Role of Gut Microbiota in Alzheimer's Disease Pathogenesis and Therapeutics.

INTRODUCTION Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β (Aβ) accumulation, tau hyperphosphorylation, and cognitive decline. Increasing evidence implicates the gut-brain axis as a key regulator of AD pathogenesis through immune, metabolic, and neuroendocrine pathways....

The Emerging Role of Peripheral Anti-Inflammatory Agents in Modulating Neurodegenerative Pathology: A Cross-Domain Review

Neurodegenerative diseases are increasingly recognized as complex, multisystem disorders involving dynamic interactions among the gut microbiota, peripheral immune system, and central nervous system. Emerging evidence suggests that alterations in gut microbial composition and chronic peripheral inflammation activel...

Gut Microbiota, Neuroinflammation, and Autonomic Dysfunction in Neurodegenerative Diseases: A Systematic Review of Mechanistic and Translational Evidence

Neurodegenerative disorders, including Parkinson's disease, Alzheimer's disease, multiple system atrophy, and amyotrophic lateral sclerosis, are increasingly recognized as complex conditions arising from interactions among the gut microbiota, immune system, and autonomic nervous system. Growing evidence indicates that...

The Gut-Brain Axis in Neurodegeneration: Mechanistic Links Between Dysbiosis and Neuropathology

Background & Objective: The gut-brain axis is essentially a two-way communication system that physically connects the brain and the intestinal tract. The connection is mediated through a series of pathways, including neural, endocrine, and immune pathways. Gut dysbiosis, which is explained as an imbalance in the microb...

Gut Microbiota Dysregulation in Dementia: Molecular Mechanism Linking the Gut-Brain Axis to Neurodegeneration.

Dementia is a progressive neurodegenerative syndrome characterised by cognitive decline, synaptic dysfunction, and neuronal loss. In recent years, growing attention has been given to the role of the gut-brain axis in neurodegenerative disease. Emerging evidence indicates that changes in gut microbiota composition and m...

The gut microbiota-miRNA axis in multiple sclerosis: Mechanisms and therapeutic potentials.